Oct 14, 1977

Glycoprotein secretion in the mouse submandibular gland as revealed by radioautography after L-3H-fucose injection

Cell and Tissue Research
T G LimaF Fava-de-Moraes

Abstract

Glycoprotein secretion in the mouse submandibular gland was investigated by light microscope radioautography of semi-thin sections after the administration of L-3H-fucose. The incorporation of the precursor in the acini was negligible. 3H-fucose was taken up in the paranuclear region of the cells lining the intercalated, secretory, striated and excretory ducts. This labeling pattern was interpredted as addition of the precursor to glycoproteins within the Golgi apparatus. Incoropration in the intercalated duct was restricted to the cells with fine cytoplasmic granules. The glycoproteins synthesized by the intercalated and secretory ducts were transported to the saliva by the secretion granules. It is assumed that the glycoproteins synthesized in the striated and excretory ducts are plasma membrane glycoproteins which seem to renew continuously. Quantitation of the radioautographs supplied data concerning the incorporation of 3H-fucose into newly synthesized glycoproteins as well as the renewal of the labeled macromolecules in each duct.

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Mentioned in this Paper

Entire Duct
Glycoprotein Secretion
Golgi Apparatus
Glycoproteins
Saliva - SpecimenType
Process of Secretion
Body Parts - Canal
Intercalated Duct
Neoglycoproteins
Macromolecule

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