PMID: 8592083Jan 1, 1996Paper

Glycoproteins of the carcinoembryonic antigen (CEA) family are expressed in sweat and sebaceous glands of human fetal and adult skin

The Journal of Investigative Dermatology
D MetzeT A Luger

Abstract

The carcinoembryonic antigen (CEA) family comprises a group of glycoproteins including the classical CEA, nonspecific cross-reacting antigens (NCA), and biliary glycoprotein (BGP). CEA glycoproteins have been identified in many glandular and mucosal tissues. In view of their putative role in cell adhesion, protein sorting, and signal transduction, CEA glycoproteins are thought to be involved in embryogenesis, architectual integrity, and secretory mechanisms of glandular epithelia. Since there are few data available on the expression of CEA-like proteins in human skin, the aim of this study was to immunohistochemically specify and localize the CEA glycoproteins in cutaneous adult and fetal glands using a panel of well-characterized antibodies. The secretory parts of eccrine sweat glands expressed CEA, NCA-90, and BGP, whereas apocrine glands remained unreactive for CEA glycoproteins. The ductal epithelia of both eccrine and apocrine glands contained CEA and NCA-90. Sebaceous glands were stained for BGP only. Electron microscopy of sweat glands showed CEA glycoprotein expression in cytoplasmic organelles and on microvilli lining the ductal surface. In sebaceous glands, BGP were demonstrated in small vesicles and along the cell me...Continue Reading

References

Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R K WilliamsK V Holmes
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·Y HinodaR J Paxton
Jan 1, 1989·The Journal of Investigative Dermatology·D MetzeG Niebauer
Jan 1, 1988·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·J Thompson, W Zimmermann
May 1, 1988·The Journal of Investigative Dermatology·T OkadaJ Asai
Apr 1, 1986·The British Journal of Dermatology·D W Cotton
Mar 1, 1974·The Journal of Investigative Dermatology·M Bell
Sep 1, 1965·The Journal of Investigative Dermatology·K HashimotoW F Lever
Apr 1, 1984·Pediatric Dermatology·N S PenneysB E Buck
Jan 1, 1984·International Review of Cytology·K KurosumiT Ito
Apr 1, 1981·Journal of the American Academy of Dermatology·N S PenneysE C McKinney
Sep 9, 1993·International Journal of Cancer. Journal International Du Cancer·S DanielF Grunert
Jan 1, 1993·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·H H HagemeierC Sorg

❮ Previous
Next ❯

Citations

Jul 25, 2000·The British Journal of Dermatology·K EgawaT Ono
Aug 11, 2017·PloS One·Patricia KlakaThomas Förster
Feb 11, 2009·Southern Medical Journal·Julie M Swick, Pearon G Lang
Jul 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·E DanielsN Beauchemin
Aug 2, 2019·Journal of Medical Case Reports·Kazuhiro MatsuedaMotowo Mizuno
Nov 6, 2007·Archives of Pathology & Laboratory Medicine·Iskander H Chaudhry, Artur Zembowicz
Jul 20, 1999·Dermatologic Clinics·A R Hudson, B R Smoller
Sep 24, 2009·Journal of Pharmaceutical Sciences·Shweta R UrvaJoseph P Balthasar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.