PMID: 109077Dec 1, 1978

Glycosaminoglycan accumulation with partial deficiency of beta-glucuronidase in the C3H strain of mice

Biochemical Genetics
S YatzivW V Robertson

Abstract

Young (60--80 days) mice of the low beta-glucuronidase strain, C3H/HeJ, showed no differences in hepatic levels of glycosaminoglycans (GAGs) when compared to the randombred, "normal" Swiss-Webster mice of the same age. However, by 12 months of age hepatic GAG is nearly twice as high in C3H/HeJ mice as in Swiss-Webster mice. Studies of beta-glucuronidase, beta-galactosidase, and N-acetyl-beta-glucosaminidase in four tissues of the two types of mice at the two ages revealed that glucuronidase was the only enzyme with lower activity in the C3H/HeJ strain.

References

Mar 1, 1975·The Journal of Pediatrics·A L BeaudetC E Mullins
Apr 1, 1975·Journal of Cellular Physiology·K PaigenR E Ganschow
Jul 15, 1974·Humangenetik·J GehlerH Drube
May 30, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·R SandmanS L Kountz
May 1, 1974·Archives of Ophthalmology·M M LaVail, R L Sidman
Oct 1, 1958·A.M.A. Archives of Ophthalmology·W K NOELL
Oct 1, 1962·Analytical Biochemistry·T BITTER, H M MUIR
Sep 15, 1957·Proceedings of the National Academy of Sciences of the United States of America·D H Brown

Citations

Aug 1, 1986·European Journal of Pediatrics·P MogleS Yatziv
Dec 18, 2013·The Journal of Clinical Investigation·Kenneth K C BramwellJanis J Weis
Jan 1, 1984·Teratogenesis, Carcinogenesis, and Mutagenesis·S E Lewis
Jul 15, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kenneth K C BramwellJanis J Weis

Related Concepts

Senility
Metazoa
Lactrase
Exo-beta-D-Glucuronidase
Glycosaminoglycans
Glucosaminidases
Kidney
Liver
Mice, Inbred C3H
Spleen

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Incretins

Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.