PMID: 6410022Aug 1, 1983Paper

Glycosaminoglycan alterations in rat bone due to growth and fluorosis

The Journal of Nutrition
C W Prince, J M Navia

Abstract

Evidence in the literature has suggested that alterations in bone glycosaminoglycans (GAGs) are at least partially responsible for the defective calcification in skeletal fluorosis. The major objectives of this study were to quantitate the GAGs of bone from normal and fluorotic rats and to characterize the change in bone GAGs that occurred during maturation. Weanling male rats were fed a semipurified diet and deionized water with or without fluoride (125 ppm) for 1 or 2 months. Also, a control group of rats was pair-fed to the rats receiving fluoride. GAGs were isolated from dry, fat-free tibias and then quantitated by digestion with chondroitinases and chondrosulfatases. Chondroitin-4-sulfate (C4S) comprised 90% of the bone GAGs, while chondroitin-6-sulfate (C6S), dermatan sulfate (DS) and hyaluronic acid (HA) together comprised about 10% of the total bone GAGs. With increasing age, total GAGs, C4S and HA decreased in amount, but DS remained constant. Fluorotic bone (containing in excess of 5000 ppm of fluoride) had three times as much C6S and twice as much DS as bone from weight- and age-matched control rats. Thus, using a controlled experimental animal model, we have demonstrated that specific alterations of bone GAGs result...Continue Reading

Citations

Mar 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P Chavassieux
Oct 12, 2013·Journal of Materials Science. Materials in Medicine·Matthias C SchulzVera Hintze
Mar 12, 2015·Scientific Reports·Toshiyasu KoikeHiroshi Kitagawa
Feb 1, 1992·Australian Dental Journal·D J HarbrowP A Monsour
Jan 1, 1985·Connective Tissue Research·M B ContriI P Ronchetti
Apr 1, 1988·Pharmacology & Toxicology·T AmmitzbøllJ Kragstrup
Dec 22, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Juliane SalbachLorenz C Hofbauer
Mar 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B H WiersD J Baylink
Oct 18, 2001·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·G EmberyM Goldberg
Jun 1, 1996·European Journal of Oral Sciences·R C HallR J Waddington
Dec 21, 2013·Journal of Cellular Biochemistry·Juliane Salbach-HirschLorenz C Hofbauer
Jul 23, 2016·Biomaterials Science·Gulistan TansikAyse B Tekinay
Apr 25, 2003·Archives of Oral Biology·A M MilanG Embery
Oct 10, 2015·ACS Applied Materials & Interfaces·Sandra RotherDieter Scharnweber

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.