Glycosaminoglycan-based hybrid hydrogel encapsulated with polyelectrolyte complex nanoparticles for endogenous stem cell regulation in central nervous system regeneration

Biomaterials
Wei-Hong JianTzu-Wei Wang

Abstract

The poor regenerative capability of stem cell transplantation in the central nervous system limits their therapeutic efficacy in brain injuries. The sustained inflammatory response, lack of structural support, and trophic factors deficiency restrain the integration and long-term survival of stem cells. Instead of exogenous stem cell therapy, here we described the synthesis of nanohybrid hydrogel containing sulfated glycosaminoglycan-based polyelectrolyte complex nanoparticles (PCN) to mimic the brain extracellular matrix and control the delivery of stromal-derived factor-1α (SDF-1α) and basic fibroblast factor (bFGF) in response to matrix metalloproteinase (MMP) for recruiting endogenous neural stem cells (NSC) and regulating their cellular fate. Bioactive factors are delivered by electrostatic sequestration on PCN to amplify the signaling of SDF-1α and bFGF to regulate NSC in vitro. In in vivo ischemic stroke model, the factors promoted neurological behavior recovery by enhancing neurogenesis and angiogenesis. These combined strategies may be applied for other tissue regenerations by regulating endogenous progenitors through the delivery of different kinds of glycosaminoglycan-binding molecules.

Citations

Feb 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariana I NevesCristina C Barrias
May 3, 2020·Polymers·Agata Krywko-CendrowskaWolfgang Meier
Jun 12, 2019·Pharmaceutics·Raluca Ioana TeleanuDaniel Mihai Teleanu
Aug 14, 2018·Advanced Healthcare Materials·Clara R CorreiaJoão F Mano
Dec 9, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chun-Yi YangTzu-Wei Wang
Nov 5, 2019·Research in Veterinary Science·Lijun GuanZhanqin Zhao
Feb 12, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zongyu XieXiaojing Wang
Oct 16, 2020·Journal of Stroke·Shuai ZhangXiaofeng Jia
Dec 3, 2020·Biomolecules·Alfonso Maria PonsiglioneEnza Torino
Oct 23, 2020·Advanced Drug Delivery Reviews·Xin DingPeiyan Yuan
Jun 3, 2021·Life·Sara Bernardo-CastroJoão Sargento-Freitas

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