PMID: 3746384Jan 1, 1986Paper

Glycosaminoglycan changes in human gliomas. A biochemical study

Journal of Neuro-oncology
A BertolottoD Schiffer

Abstract

Glycosaminoglycans (GAGs) were isolated, separated by electrophoresis and quantified in 36 neurosurgical specimens of human gliomas and in 8 samples of normal white and gray matter. Gliomas of various degrees of malignancy exhibited different GAG patterns. Total GAG concentration was three times higher in low grade gliomas than in normal white matter. The mean percentage of single GAG classes was usually similar in both tissues, although in certain tumor samples a higher percentage of hyaluronate was found. GAG patterns in anaplastic astrocytomas, however, more closely resembled normal white and gray matter, both quantitatively and qualitatively. Glioblastomas, on the other hand, showed high GAG concentrations, in particular of heparan sulfate and dermatan sulfate. This finding could be secondary to the abundant vessels and mesodermal material associated with this oncotype. The hyaluronate/sulfated GAGs ratio was lower in oligodendrogliomas than in low grade astrocytomas. This biochemical feature may be correlated with the alcianophilia found in the honey-comb degeneration of oligodendrogliomas. The significance of these findings as they relate to tumor histology and biology have been discussed.

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Citations

Jan 1, 1986·Acta Neuropathologica·A BertolottoD Schiffer
Jan 1, 1993·Journal of Neuro-oncology·M Wiranowska, A K Naidu
Dec 1, 1990·Journal of the Neurological Sciences·A BertolottoD Schiffer
May 1, 1992·Journal of Neurosurgery·W T CouldwellM C Kuppner
Sep 21, 2013·Tissue Engineering. Part B, Reviews·Shreyas S RaoJessica O Winter
Feb 20, 1992·International Journal of Cancer. Journal International Du Cancer·M C KuppnerN de Tribolet
Oct 7, 2014·The FEBS Journal·Anqi XiongKarin Forsberg-Nilsson
Mar 1, 1997·Research in Veterinary Science·M CastagnaroF Guarda
Aug 10, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Meghan T LogunLohitash Karumbaiah
Jul 11, 2020·Nature Reviews. Materials·Kayla J WolfSanjay Kumar
Aug 1, 1996·Neurosurgery·A Giese, M Westphal
Jun 1, 1991·Journal of Neuroscience Research·A BertolottoD Schiffer

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