Glycosaminoglycan chemical exchange saturation transfer of lumbar intervertebral discs in patients with spondyloarthritis

Journal of Magnetic Resonance Imaging : JMRI
Christoph SchleichFalk Miese

Abstract

To assess glycosaminoglycan (GAG) content of lumbar intervertebral discs (IVD) in patients with spondyloarthritis (SpA) using glycosaminoglycan chemical exchange saturation transfer (gagCEST). Ninety lumbar intervertebral discs of nine patients with SpA and nine age-matched healthy controls (eight patients with ankylosing spondylitis; one patient with spondylitis related to inflammatory bowel disease; mean age: 44.1 ± 14.0 years; range: 27-72 years) were examined with a 3T magnetic resonance imaging (MRI) scanner in this prospective study. The MRI protocol included standard morphological, sagittal T2 -weighted (T2 w) images to assess Pfirrmann score of the five lumbar IVDs (L1 to S1) and biochemical imaging with gagCEST to calculate a region of interest analysis of nucleus pulposus (NP) and annulus fibrosus (AF). Prior to statistical testing of gagCEST effects (MTRasym values in percent) in patients and controls, IVDs were classified according to the Pfirrmann score. Significantly lower gagCEST values of NP and AF were found in SpA patients compared with healthy volunteers (NP: 1.41% ± 0.41%, P = 0.001; 95% confidence interval, CI [0.600%-2.226%]; AF: 1.19% ± 0.32%, P < 0.001; CI [0.560%-1.822%]) by comparing the differences of...Continue Reading

References

Apr 27, 2005·Joint, Bone, Spine : Revue Du Rhumatisme·Sandrine LangloisDaniel Wendling
Jan 30, 2007·Journal of Magnetic Resonance Imaging : JMRI·Jill P G Urban, C Peter Winlove
Feb 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Wen LingAlexej Jerschow
Mar 19, 2009·Clinical Rheumatology·Johannes L BronBarend J van Royen
Apr 10, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mina KimPeter C M van Zijl
May 25, 2010·Clinical Rheumatology·Mirjam K de VriesIrene E van der Horst-Bruinsma
Jan 17, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G VarmaE Vinogradov
May 16, 2012·Annals of the Rheumatic Diseases·Kay-Geert A HermannUNKNOWN Assessment in SpondyloArthritis international Society (ASAS)
Jun 28, 2012·Annals of the Rheumatic Diseases·Christian E AlthoffKay-Geert A Hermann
Oct 17, 2012·The Journal of Rheumatology·Rosario PelusoRaffaele Scarpa
Dec 21, 2012·AJR. American Journal of Roentgenology·Clarissa CanellaEdson Marchiori
Jan 1, 2013·Best Practice & Research. Clinical Rheumatology·Susanne J PedersenMikkel Ostergaard
Oct 4, 2014·Osteoarthritis and Cartilage·C RehnitzM-A Weber
Oct 24, 2014·Skeletal Radiology·Anja Müller-LutzFalk Miese

❮ Previous
Next ❯

Citations

Aug 4, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Anja Müller-LutzHans-Jörg Wittsack
Sep 20, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Pernilla PetersonJonas Svensson
Aug 10, 2017·Journal of Magnetic Resonance Imaging : JMRI·Kyle M JonesMark D Pagel
Jan 31, 2020·NMR in Biomedicine·Emma EinarssonJonas Svensson
May 22, 2019·World Journal of Radiology·Mohamed R Nouh
Aug 18, 2021·Journal of Science and Medicine in Sport·M FrenkenS Nebelung

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.