PMID: 9179577May 1, 1997Paper

Glycosaminoglycan depletion greatly raises the hydraulic permeability of rabbit joint synovial lining

Experimental Physiology
D ScottJ R Levick

Abstract

The hydraulic resistance of the synovial lining of a joint is important for retention of intraarticular lubricant. The resistance has been attributed to synovial interstitial glycosaminoglycans. This was tested by depletion of hyaluronan and chondroitin sulphates from synovium in five rabbit knees in vivo under anaesthesia, using testicular hyaluronidase. The enzyme raised synovial permeability to fluid 5- to 7-fold-substantially more, in fact, than predicted by a recent model. The results prove that hyaluronan and/or chondroitin sulphate are important sources of hydraulic resistance in synovium.

Citations

Aug 25, 1999·Microvascular Research·S ParameswaranS J Lai-Fook
Apr 11, 2003·Microvascular Research·Sonja M Moe, Stephen J Lai-Fook
Aug 13, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Wen-Ting ZhouWei-Bo Zhang
Dec 19, 2003·Journal of Telemedicine and Telecare·Ran KornowskiShai Misan
Feb 10, 1999·The American Journal of Physiology·E R ZakariaM F Flessner

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