PMID: 8581533Jan 1, 1995Paper

Glycosaminoglycans in intervertebral disc amyloid deposits

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
N A AthanasouB Puddle

Abstract

Intervertebral discs are a common site of localized articular and some forms of systemic articular amyloid deposition. Whether there is an intrinsic matrix factor that favours amyloid deposition in intervertebral disc connective tissues is uncertain, but it is known that small localized deposits of amyloid in intervertebral discs are largely age related. As the glycosaminoglycans (GAGs) composition of the intervertebral disc is known to change with age, and as some forms of systemic amyloid deposition have been shown to be associated with particular highly sulphated GAGs, we examined the GAGs profile of amyloid deposits in intervertebral discs using mucin histochemistry (Alcian blue: MgCl2 critical electrolyte concentration) and immunohistochemistry. We found strong staining for very highly sulphated GAGs (0.9 M and 1 M MgCl2) and confirmed the presence of keratan sulphate in both localized and systemic, dialysis-associated beta 2-microglobulin amyloid deposits within disc fibrocartilage. These findings suggest that qualitative and quantitative changes in matrix GAGs, particularly strongly sulphated GAGs such as keratan sulphate, may play a role in the pathogenesis of localized and systemic amyloid deposition in intervertebral ...Continue Reading

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Citations

Mar 23, 2006·Seminars in Dialysis·Laura M Dember, Bertrand L Jaber
Apr 30, 2016·The Spine Journal : Official Journal of the North American Spine Society·Nukala Sarath BabuMohammed M Idris
Apr 19, 2011·Journal of Neurosurgery. Spine·Vincent C Traynelis
Jan 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Koen J A JansensJan A Delcour

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