Glycosaminoglycans of normal veins and their alterations in varicose veins and varicose veins complicated by thrombophlebitis

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
M WolańskaA Płoński

Abstract

The aim of the study was to examine the content and molecular differentiation of glycosaminoglycans (GAGs) in the wall of varicose veins. The studied material consisted of normal, varicose veins and varicose veins complicated by thrombophlebitis collected during operations on 26 patients. In the wall of varicose veins the mean GAGs' content as well as the content of sulphated GAGs, except heparan sulphate was increased, whereas the amount of hyaluronic acid was decreased. Furthermore, the increased quantitative ratio between sulphated and nonsulphated GAGs was demonstrated. The results indicate an evident extracellular matrix remodelling in the wall of varicose veins particularly those complicated by thrombophlebitis, that is characterised by alterations in the content and molecular differentiation of GAGs.

Citations

Apr 12, 2011·Folia Histochemica Et Cytobiologica·Radoslaw KowalewskiKrzysztof Sobolewski
Aug 13, 2013·Seminars in Vascular Surgery·Jovan N Markovic, Cynthia K Shortell
Apr 28, 2009·The Journal of Surgical Research·Radoslaw KowalewskiMarek Gacko
Jun 12, 2014·Expert Review of Molecular Diagnostics·Ferdinando MannelloJoseph D Raffetto
Aug 21, 2019·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Marta Bruczko-GoralewskaRadosław Kowalewski

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