PMID: 9543724Apr 17, 1998Paper

Glycosidopyrroles. Part 1. Acyclic derivatives: 1-(2-hydroxyethoxy)methylpyrroles as potential anti-viral agents

Il Farmaco
A M AlmericoP La Colla

Abstract

Acyclic glycosidopyrroles of type 1, synthesized in good overall yields, were evaluated for anti-viral activity. Compound 10i was found to inhibit the HIV-1 replication at concentrations that were very close to those cytotoxic for MT-4 cells. Compounds 10a,f,i inhibited both strains HSV-1 and HSV-2 at concentrations slightly below those cytotoxic for Vero cells. However for this series of glycosidopyrroles some relationship between calculated log P values and the observed cytotoxicity was found.

References

Mar 4, 1977·Annals of the New York Academy of Sciences·P Collins, D J Bauer
Aug 1, 1988·Journal of Virological Methods·R PauwelsE De Clercq

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Citations

Feb 13, 2001·Journal of Virological Methods·N O FischerR I Woodruff
Nov 5, 2011·European Journal of Medicinal Chemistry·Mosaad S MohamedRania H Abd El-Hameed

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