Glycosphingolipids from Sphingomonas paucimobilis induce monokine production in human mononuclear cells.

Infection and Immunity
C KrziwonA J Ulmer

Abstract

Glycosphingolipids (GSL) isolated from the gram-negative lipopolysaccharide (LPS)-free bacterium Sphingomonas paucimobilis have remarkable structural similarities with LPS and its hydrophobic part, termed lipid A. Like LPS, but in contrast to the structurally related ceramides and cerebrosides, GSL contain an alpha-linked, negatively charged pyranosidic glycosyl component adjacent to the lipid portion and are capable of forming membranes. Because of these similarities, it was of interest to investigate whether these GSL are also able to induce monokine production in human mononuclear cells (MNC). Our results show that a GSL containing four sugar residues (GSL-4A) induced the release of tumor necrosis factor, interleukin-6, and interleukin-1 in MNC, whereas GSL-1, containing only one glycosyl residue, was inactive. A minimal concentration of 1 microgram of GSL-4A per ml was necessary to induce monokine production in MNC, whereas LPS was as active at a 10,000-fold-lower concentration (0.1 ng/ml). Both GSL-4A-induced monokine production and LPS-induced monokine production were reduced by the bactericidal/permeability-increasing protein and GSL-1. In contrast to LPS, GSL-4A-induced monokine release could be inhibited neither by an ...Continue Reading

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Citations

Apr 9, 1998·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·E T RietschelA J Ulmer
Oct 29, 2000·Journal of Applied Microbiology·R KoskinenM Salkinoja-Salonen
May 26, 2005·European Journal of Immunology·Venkataraman SriramRandy R Brutkiewicz
Jul 22, 2006·Journal of Cataract and Refractive Surgery·Wendy E AdamsDavid H Steel
Dec 22, 2005·Infection and Immunity·Lena J HeungMaurizio Del Poeta
Dec 21, 2004·European Journal of Biochemistry·Evgeny VinogradovMalcolm B Perry
Mar 8, 2008·Korean Journal of Ophthalmology : KJO·Seong Wook SeoJong Moon Park
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Sep 24, 2004·Research in Microbiology·Maria Grazia AmmendoliaLucilla Baldassarri

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