PMID: 6632725Sep 1, 1983Paper

Glycosylated hemoglobin as a long-term parameter in appraising the severity of hemolytic disease

Klinische Wochenschrift
S PanzerK Lechner

Abstract

Reduced levels of glycosylated hemoglobins (GHb) have been found to be closely related to red cell survival. We therefore studied the relation of this parameter to the clinical applicability in patients with hemolytic disease (n = 20). During a 5-week period we repeatedly measured severity of anemia, i.e., hemoglobin (Hb), packed red cell volume (VPRC), and red blood cell count (RBC), as well as reticulocytosis and parameters of red cell destruction such as serum concentration of lactic dehydrogenase (LDH) and bilirubin together with GHb. There was a weak correlation between simultaneously measured GHb and RBC (r = 0.5, P = 0.02), but none was demonstrable between GHb and Hb, VPRC, reticulocyte counts, LDH, or bilirubin. A much closer correlation, however, was found between actual GHb levels and RBC determined 3-5 weeks previously (r = 0.72, P = 0.001), as well as Hb (r = 0.56, P = 0.015), VPRC (r = 0.57, P = 0.013), reticulocyte counts (r = -0.63, P = 0.006), LDH ( r = -0.53, P = 0.02), and serum bilirubin concentrations ( r = -0.55, P = 0.016). Ghb was also significantly decreased in patients with consistently low values of reticulocytes when red cell destruction was demonstrable. These results show that GHb is a measure of r...Continue Reading

References

May 1, 1977·The Journal of Clinical Endocrinology and Metabolism·K H GabbayP M Gallop
Jun 1, 1976·The Journal of Clinical Investigation·H F BunnP M Gallop
Aug 19, 1976·The New England Journal of Medicine·R J KoenigA Cerami
Oct 1, 1976·The Journal of Clinical Investigation·J F FitzgibbonsR T Jones
Feb 1, 1974·Postgraduate Medicine·J E MaldonadoL J Schoenfield
Feb 1, 1973·Metabolism: Clinical and Experimental·E P Paulsen
Oct 1, 1971·Nature·J K MarkhamN V Owen
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Feb 18, 1971·The New England Journal of Medicine·L A TrivelliH T Lai
Aug 26, 1971·The New England Journal of Medicine·A Opalinski, E Beutler
Jun 1, 1981·The Journal of Clinical Endocrinology and Metabolism·H VierhapperW Waldhäusl
Feb 4, 1982·The New England Journal of Medicine·C L ConleyM T Gallagher
May 22, 1981·JAMA : the Journal of the American Medical Association·J Fehr

Citations

Aug 21, 2010·Endocrine Journal·Masafumi Koga, Soji Kasayama
Apr 1, 2014·Endocrine Journal·Kaori InoueMitsuhiko Noda
Oct 23, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Masafumi KogaSoji Kasayama
Aug 28, 2015·Photochemistry and Photobiology·Devi Kalyan KarumanchiJames Dillon
Mar 18, 2015·American Journal of Hematology·H Franklin Bunn
Mar 19, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Masafumi Koga
May 15, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Cai-Mei ZhengKuo-Cheng Lu
Sep 10, 2008·Primary Care Diabetes·Ossama BarakatKetan Dhatariya
Apr 11, 2017·Critical Reviews in Clinical Laboratory Sciences·Sara YazdanpanahLobat Tayebi
May 9, 2006·American Journal of Hematology·Benjamin L MitlyngMichael D Levitt

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