Glycosylated hemoglobin concentration for assessment of glycemic control in diabetic cats

Journal of Veterinary Internal Medicine
D A ElliottL A Neal

Abstract

Blood glycosylated hemoglobin (GHb) concentration was quantified in 84 healthy cats, 9 cats with stress-induced hyperglycemia, 37 cats with newly diagnosed diabetes mellitus, and 122 diabetic cats treated with insulin or glipizide. Diabetic control was classified as good or poor in insulin-treated or glipizide-treated cats based on review of history, physical examination findings, changes in body weight, and measurement of blood glucose concentrations. Blood GHb concentration was determined using an affinity chromatography assay. Mean blood GHb concentration was similar for healthy normoglycemic cats and cats with transient, stress-induced hyperglycemia, but was significantly (P < .001) higher in untreated diabetic cats when compared with healthy normoglycemic cats. Mean blood GHb concentration was significantly (P < .001) higher in 84 cats with poorly controlled diabetes mellitus when compared with 38 cats in which the disease was well controlled. Mean blood GHb concentration decreased significantly (P < .01) in 6 cats with untreated diabetes mellitus after insulin and dietary treatment. A similar significant (P < .01) decrease in mean blood GHb concentration occurred in 7 cats with poorly controlled diabetes mellitus after di...Continue Reading

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Citations

Mar 19, 1999·Domestic Animal Endocrinology·M Hoenig, D C Ferguson
Jan 3, 2006·Diabetes Technology & Therapeutics·Charles E WiedmeyerAmy E DeClue
Feb 8, 2011·Clinics in Laboratory Medicine·Charles E Wiedmeyer, Amy E DeClue
Sep 21, 2006·The Veterinary Clinics of North America. Small Animal Practice·Ellen N Behrend
Sep 11, 2002·Clinical Techniques in Small Animal Practice·Craig B Webb
Jan 4, 2005·The Veterinary Clinics of North America. Small Animal Practice·Jacquie S Rand, Rhett D Marshall
Sep 26, 2001·The Veterinary Clinics of North America. Small Animal Practice·J S Rand, G J Martin
Nov 22, 2001·Journal of Feline Medicine and Surgery·G Martin, J Rand
Apr 8, 2000·Journal of the American Veterinary Medical Association·R W NelsonL A Neal
Oct 14, 2003·Journal of the American Veterinary Medical Association·Charles E WiedmeyerRichard L Meadows

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