Glycosylation characteristics of colorectal cancer

Advances in Cancer Research
Stephanie HolstYoann Rombouts

Abstract

Glycans on proteins and lipids are known to alter with malignant transformation. The study of these may contribute to the discovery of biomarkers and treatment targets as well as understanding of cancer biology. We here describe the change of glycosylation specifically defining colorectal cancer with view on N-glycans, O-glycans, and glycosphingolipid glycans in colorectal cancer cells and tissues as well as patient sera. Glycan alterations observed in colon cancer include increased β1,6-branching and correlating higher abundance of (poly-)N-acetyllactosamine extensions of N-glycans as well as an increase in (truncated) high-mannose type glycans, while bisected structures decrease. Colorectal cancer-associated O-glycan changes are predominated by reduced expression of core 3 and 4 glycans, whereas higher levels of core 1 glycans, (sialyl) T-antigen, (sialyl) Tn-antigen, and a generally higher density of O-glycans are observed. Specific changes for glycosphingolipid glycans are lower abundances of disialylated structures as well as globo-type glycosphingolipid glycans with exception of Gb3. In general, alterations affecting all discussed glycan types are increased sialylation, fucosylation as well as (sialyl) Lewis-type antigens...Continue Reading

Citations

Mar 25, 2016·Journal of the American Chemical Society·Jiahn-Haur LiaoShih-Hsiung Wu
Jul 18, 2015·Journal of Proteome Research·Norelle C WildburgerCarol L Nilsson
May 6, 2016·Frontiers in Oncology·Kekoa TaparraNatasha E Zachara
Mar 21, 2017·Oncogenesis·A Vasconcelos-Dos-SantosA R Todeschini
Dec 23, 2015·International Journal of Molecular Sciences·Manveen K Sethi, Susan Fanayan
Oct 11, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ulisses Moreno-CelisTeresa García-Gasca
May 6, 2019·Proteomics. Clinical Applications·Ana PenezićOlgica Nedić
Sep 4, 2016·Analytical and Bioanalytical Chemistry·Muchena J KailemiaCarlito B Lebrilla
Sep 12, 2019·FEBS Letters·Viktoria Dotz, Manfred Wuhrer
Apr 30, 2020·The Biochemical Journal·Gabrielle E CervoniRichard D Cummings
Aug 11, 2018·Oncotarget·Stefan W de VroomeManfred Wuhrer
Sep 27, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ryan P BergerStephen Dalton
Aug 11, 2015·Diseases·Mukesh Verma, Hirendra Nath Banerjee
Apr 29, 2020·Laboratory Investigation; a Journal of Technical Methods and Pathology·Bram HeijsJudith V M G Bovée
Oct 7, 2017·Breast Cancer Research : BCR·Cheng-Fen TuRuey-Bing Yang
Sep 21, 2017·Science Advances·Moran Frenkel-PinterDaniel Segal
Aug 28, 2019·Cancers·Tyler S KeeleyEric Lau
Jun 26, 2020·Glycoconjugate Journal·Ruifeng BaiYin Gao
Sep 29, 2020·Beilstein Journal of Organic Chemistry·Akul Y MehtaRichard D Cummings
Aug 6, 2019·Clinical and Experimental Pharmacology & Physiology·Siyao WangShun Xu
Apr 3, 2020·Cellular and Molecular Life Sciences : CMLS·Katarina MadunićManfred Wuhrer

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