Mar 15, 2018

Glycosylation of extracellular vesicles: current knowledge, tools and clinical perspectives

Journal of Extracellular Vesicles
Charles WilliamsJuan M Falcon-Perez

Abstract

It is now acknowledged that extracellular vesicles (EVs) are important effectors in a vast number of biological processes through intercellular transfer of biomolecules. Increasing research efforts in the EV field have yielded an appreciation for the potential role of glycans in EV function. Indeed, recent reports show that the presence of glycoconjugates is involved in EV biogenesis, in cellular recognition and in the efficient uptake of EVs by recipient cells. It is clear that a full understanding of EV biology will require researchers to focus also on EV glycosylation through glycomics approaches. This review outlines the major glycomics techniques that have been applied to EVs in the context of the recent findings. Beyond understanding the mechanisms by which EVs mediate their physiological functions, glycosylation also provides opportunities by which to engineer EVs for therapeutic and diagnostic purposes. Studies characterising the glycan composition of EVs have highlighted glycome changes in various disease states, thus indicating potential for EV glycans as diagnostic markers. Meanwhile, glycans have been targeted as molecular handles for affinity-based isolation in both research and clinical contexts. An overview of cu...Continue Reading

Mentioned in this Paper

Biological Markers
Study
Research
Extracellular
Isolation Aspects
Uptake
Research Personnel
Vesicle
Intercellular Transport
Protein Glycosylation

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