Glycosylation of PrPC determines timing of neuroinvasion and targeting in the brain following transmissible spongiform encephalopathy infection by a peripheral route.

Journal of Virology
Enrico CancellottiJean C Manson

Abstract

Transmissible spongiform encephalopathy (TSE) infectivity naturally spreads from site of entry in the periphery to the central nervous system where pathological lesions are formed. Several routes and cells within the host have been identified as important for facilitating the infectious process. Expression of the glycoprotein cellular PrP (PrP(C)) is considered a key factor for replication of infectivity in the central nervous system (CNS) and its transport to the brain, and it has been suggested that the infectious agent propagates from cell to cell via a domino-like effect. However, precisely how this is achieved and what involvement the different glycoforms of PrP have in these processes remain to be determined. To address this issue, we have used our unique models of gene-targeted transgenic mice expressing different glycosylated forms of PrP. Two TSE strains were inoculated intraperitoneally into these mice to assess the contribution of diglycosylated, monoglycosylated, and unglycosylated PrP in spreading of infectivity to the brain. This study demonstrates that glycosylation of host PrP has a profound effect in determining the outcome of disease. Lack of diglycosylated PrP slowed or prevented disease onset after periphera...Continue Reading

References

Mar 1, 1989·Virus Research·R H Kimberlin, C A Walker
Jun 1, 1987·Microbial Pathogenesis·R H KimberlinC A Walker
Jul 2, 1993·Cell·H BüelerC Weissmann
Apr 6, 1996·Lancet·R G WillP G Smith
Oct 1, 1996·The Journal of General Virology·J R Fraser
Mar 31, 1998·The Journal of General Virology·M BeekesE Baldauf
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·G ZanussoM S Sy
Aug 6, 1998·Annals of Hematology·J E GessnerR E Schmidt
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·S B Prusiner
Oct 20, 2000·The Journal of General Virology·M Glatzel, A Aguzzi
Nov 9, 2000·Neurology·P BrownS J Collins
Apr 13, 2001·Biochemistry·P M RuddR A Dwek
Oct 3, 2003·British Medical Bulletin·Moira E Bruce
Oct 3, 2003·British Medical Bulletin·Robert G Will
Aug 11, 2004·Lancet·Alexander H PedenJames W Ironside
Apr 13, 2005·Archives of Neurology·Markus GlatzelAdriano Aguzzi
Feb 8, 2006·Nature Reviews. Microbiology·Neil A Mabbott, G Gordon MacPherson
Sep 19, 2006·Nature Reviews. Microbiology·Adriano Aguzzi, Mathias Heikenwalder
Nov 1, 2006·Biochemical Society Transactions·J C MansonR M Barron
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Pedro PiccardoRona M Barron

❮ Previous
Next ❯

Citations

Sep 8, 2010·The Journal of Biological Chemistry·Pedro Fernandez-FunezDiego E Rincon-Limas
Aug 30, 2012·The Journal of Biological Chemistry·Helen M J KlemmVictoria A Lawson
Jan 21, 2011·Journal of Virology·Muhammad K SalamatHubert Laude
Jan 16, 2016·International Journal of Molecular Sciences·Abigail B DiackJean C Manson
Oct 15, 2011·EMBO Reports·Charles WeissmannShawn Browning
Aug 16, 2016·Virology·Barry M BradfordNeil A Mabbott
May 28, 2013·Acta Biochimica Et Biophysica Sinica·Chuan-Wei YiYi Liang
Nov 19, 2015·Scientific Reports·Elizaveta KatorchaIlia V Baskakov
Mar 9, 2017·Scientific Reports·Patricia Aguilar-CalvoChristina J Sigurdson
Nov 17, 2016·Journal of Virology·Karen E MarshallGerald S Baron
Jan 1, 2016·Journal of Virology·James E VincentiJean C Manson
Mar 13, 2019·Viruses·Etienne LevavasseurStéphane Haïk
Dec 22, 2012·Expert Review of Proteomics·Edmondo CampisiMaurizio Pocchiari
Jan 16, 2016·The Journal of Biological Chemistry·Belinda B GuoAndrew F Hill
Jul 31, 2013·The Journal of Biological Chemistry·Daniela SaverioniPiero Parchi
Jan 28, 2020·The Journal of Clinical Investigation·Alejandro M SevillanoChristina J Sigurdson
Apr 5, 2017·Frontiers in Molecular Neuroscience·Rafael Linden
Jan 28, 2020·The Journal of Clinical Investigation·Jason C Bartz
Feb 6, 2020·International Journal of Molecular Sciences·Natallia MakaravaIlia V Baskakov
Jul 10, 2018·Journal of Molecular Neuroscience : MN·Shweta Kishor Sonawane, Subashchandrabose Chinnathambi
Feb 19, 2021·PLoS Pathogens·Natali NakićGiuseppe Legname
Aug 26, 2021·Molecular Cell·Allison KrausByron Caughey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.