Glycosylation patterns are sexually dimorphic throughout development of the olfactory system in Manduca sexta

The Journal of Comparative Neurology
N J GibsonL P Tolbert

Abstract

In the moth Manduca sexta, development of the adult olfactory system depends on complex interactions between olfactory receptor neurons in the antenna, antennal-lobe neurons in the brain, and several classes of glial cells. As one approach to characterizing molecules that may play roles in these interactions, we used lectins to screen antennae and antennal lobes at different stages of adult development. We find that each of the major neural cell types has a distinct pattern of labeling by lectins. Effects of enzymatic and other treatments on lectin labeling lead us to conclude that the predominant lectin ligands are: glycosphingolipids and an O-linked, fucose-containing glycoprotein on axons of olfactory receptor neurons, O-linked glycoproteins on antennal-lobe neurons, and N-linked glycoproteins on all classes of glial cells in the primary olfactory pathway. Wheat germ agglutinin labels all olfactory axons uniformly during much of development, but labeling becomes restricted to the pheromone-responsive olfactory receptor neurons in the adult male. Succinylated WGA reveals differences in these axon classes earlier, as glomerului develop from protoglomeruli. The adult female displays a less pronounced difference in labeling of a...Continue Reading

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Citations

Sep 22, 2011·Neuron Glia Biology·Mounir A KoussaLynne A Oland
Nov 18, 2006·Journal of Cellular Physiology·Timothy R Henion, Gerald A Schwarting
Jun 6, 2007·Journal of Neuroscience Research·Gerald A Schwarting, Timothy R Henion
Jun 15, 2007·Developmental Neurobiology·Gerald A Schwarting, Timothy R Henion
Dec 31, 2008·Microscopy Research and Technique·Daniela GochtRalf Heinrich
Mar 31, 2006·The Journal of Comparative Neurology·Sheena M Brown, Nicholas J Strausfeld

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