Glycosylation status of serum immunoglobulin G in patients with prostate diseases

Cancer Medicine
Saiko KazunoTsutomu Fujimura

Abstract

Occurrences of high values in patients with benign prostate disease and low values in patients with highly suspicious cancer have diminished the trustworthiness of prostate-specific antigen as an early diagnostic marker of prostate cancer. In the search for other complimentary markers, we focused on serum IgG from patients with prostate diseases as well as normal subjects. IgG purified from the sera of normal control subjects and patients with prostate diseases, was digested with peptide N-glycanase. Released glycans were quantified using MALDI-time of flight mass spectrometry. We report that N-linked (N-acetylhexosamine)2 (deoxyhexose)(mannose)3 (N-acetylglucosamine)2 was significantly increased in the IgG heavy chains of patients with prostate cancer compared with that of either benign prostatic disease patients or healthy subjects, whereas (hexose)(N-acetylhexosamine)2 (deoxyhexose)(mannose)3 (N-acetylglucosamine)2 was more abundant in the heavy chains of healthy subjects and benign prostatic disease patients. Thus, an absence of the terminal hexose of N-linked glycans has been closely connected to the progression of prostate cancer. Furthermore, surface plasmon resonance analyses have revealed that IgG from patients with pr...Continue Reading

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Citations

Dec 7, 2017·International Journal of Molecular Sciences·Toshikazu TanakaChikara Ohyama
Jan 31, 2018·Frontiers in Oncology·Raphaela Menezes de OliveiraAline Maria Araujo Martins
Nov 20, 2018·Expert Review of Proteomics·Jan TkacPeter Kasak
Mar 24, 2016·Oncotarget·Jennifer Munkley, David J Elliott
Jul 20, 2017·ACS Sensors·Jean-Francois Masson

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Methods Mentioned

BETA
glycosylation
surface
chip
PCA
surface plasmon resonance

Software Mentioned

xPONENT
OriginPro

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