Glycosylphosphatidylinositol-Anchored Immunoglobulin Superfamily Cell Adhesion Molecules and Their Role in Neuronal Development and Synapse Regulation

Frontiers in Molecular Neuroscience
Rui P A TanVladimir Sytnyk


Immunoglobulin superfamily (IgSF) cell adhesion molecules (CAMs) are cell surface glycoproteins that not only mediate interactions between neurons but also between neurons and other cells in the nervous system. While typical IgSF CAMs are transmembrane molecules, this superfamily also includes CAMs, which do not possess transmembrane and intracellular domains and are instead attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor. In this review, we focus on the role GPI-anchored IgSF CAMs have as signal transducers and ligands in neurons, and discuss their functions in regulation of neuronal development, synapse formation, synaptic plasticity, learning, and behavior. We also review the links between GPI-anchored IgSF CAMs and brain disorders.


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May 3, 2019·Proceedings of the National Academy of Sciences of the United States of America·Shouqiang ChengEngin Özkan
Dec 8, 2020·Frontiers in Molecular Neuroscience·Irina KozlovaVladimir Sytnyk
Aug 26, 2021·Neurology. Neuroimmunology and Neuroinflammation·Julia GrünerKathrin Doppler

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Methods Mentioned

antisense oligodeoxynucleotide

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