Glycosylphosphatidylinositol (GPI)-anchored membrane proteins are constitutively down-regulated in psoriatic skin

The Journal of Pathology
G T VennekerS S Asghar

Abstract

Hyperproliferation of keratinocytes (KCs) in psoriasis has been found to be associated with excessive activation of a phospholipase C (PLC)/protein kinase C (PKC) signal transduction system. The molecular species of PLCs which are activated in psoriasis have not been thoroughly investigated. It was envisaged that if glycosylphosphatidylinositol (GPI)-specific PLC was activated in the membrane of psoriatic epidermal cells, it would render these cells devoid of those proteins which are anchored to the cell membrane through their GPI moiety. In order to test this possibility, four GPI proteins (CD16, CD55, CD58, and CD59) were determined immunohistochemically in normal and psoriatic skin. In normal skin, CD55 and CD59 were strongly expressed on epithelium and vascular structures, whereas CD16 and CD58 were strongly expressed only on epithelium. The expression of all four GPI proteins was decreased in non-lesional psoriatic skin and virtually abolished in lesional psoriatic skin. A control transmembrane protein, CD46, was strongly expressed in normal and non-lesional psoriatic skin, and its expression was not significantly decreased in psoriatic lesions. The absence or reduction of GPI proteins was not seen in the lesions of severa...Continue Reading

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Citations

Dec 1, 1995·Immunotechnology : an International Journal of Immunological Engineering·Y Sugita, Y Masuho
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·D E DunnJ M Liu
Oct 18, 2011·Cellular Immunology·Bing LiYingjie Xu
Oct 9, 1998·The Journal of Investigative Dermatology·M C PaschS S Asghar
Jul 24, 2012·Journal of Cellular Biochemistry·Bing LiXian-Ming Chu
Jan 21, 2006·FEMS Yeast Research·José Ruiz-HerreraRafael Sentandreu
Jan 3, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elke WandelGabriela Aust
May 21, 2004·Journal of Gastroenterology and Hepatology·Kimihiro ShimoYasushi Shiratori
Nov 5, 1997·Biochimica Et Biophysica Acta·O NosjeanB Roux
Nov 8, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bing LiXianming Chu

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