Glycosyltransferase-mediated Sweet Modification in Oral Streptococci

Journal of Dental Research
Fan ZhuH Wu

Abstract

Bacterial glycosyltransferases play important roles in bacterial fitness and virulence. Oral streptococci have evolved diverse strategies to survive and thrive in the carbohydrate-rich oral cavity. In this review, we discuss 2 important biological processes mediated by 2 distinct groups of glycosyltransferases in oral streptococci that are important for bacterial colonization and virulence. The first process is the glycosylation of highly conserved serine-rich repeat adhesins by a series of glycosyltransferases. Using Streptococcus parasanguinis as a model, we highlight new features of several glycosyltransferases that sequentially modify the serine-rich glycoprotein Fap1. Distinct features of a novel glycosyltransferase fold from a domain of unknown function 1792 are contrasted with common properties of canonical glycosyltransferases. The second biological process we cover is involved in building sticky glucan matrix to establish cariogenic biofilms by an important opportunistic pathogen Streptococcus mutans through the action of a family of 3 glucosyltransferases. We focus on discussing the structural feature of this family as a glycoside hydrolase family of enzymes. While the 2 processes are distinct, they all produce carboh...Continue Reading

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Citations

Dec 30, 2015·Science China. Life Sciences·Fan Zhu, Hui Wu
Oct 22, 2016·Trends in Microbiology·Hanne L P Tytgat, Willem M de Vos
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Jan 2, 2021·The Journal of Biological Chemistry·Ravin SeepersaudPaul M Sullam
Nov 17, 2020·Frontiers in Microbiology·Jia Mun ChanRobert S Heyderman
Jan 12, 2021·The Journal of Biological Chemistry·Ravin SeepersaudPaul M Sullam
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Oct 1, 2021·International Journal of Oral Science·Qiong ZhangJing Zou
Dec 18, 2021·International Journal of Oral Science·Yalan DengTao Hu

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Methods Mentioned

BETA
glycosylation

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