PMID: 9437652Jan 23, 1998Paper

Glycyl-L-glutamine-enriched total parenteral nutrition maintains small intestine gut-associated lymphoid tissue and upper respiratory tract immunity

JPEN. Journal of Parenteral and Enteral Nutrition
J LiK A Kudsk

Abstract

i.v. administration of a total parenteral nutrition (TPN) solution results in small intestinal gut-associated lymphoid tissue (GALT) atrophy, lowers small intestinal immunoglobulin A (IgA) levels, and impairs upper respiratory tract secretory IgA-mediated mucosal immunity; isonitrogenous supplementation of TPN with 2% glutamine attenuates these changes. This experiment examines whether a 2% glycyl-L-glutamine-enriched TPN solution reverses i.v. TPN-induced changes as effectively as L-glutamine. Male Institute of Cancer Research (ICR) mice underwent intranasal inoculation with H1N1 influenza virus to establish immunity. After 3 weeks, mice were randomized to chow, i.v. feeding of a TPN solution, glutamine-enriched TPN, or glycyl-L-glutamine-enriched TPN. After 4 days of feeding, mice were challenged intranasally with influenza virus and killed at 40 hours to determine viral shedding from the respiratory tract; normal convalescent mice do not shed virus because they possess intact IgA-mediated mechanisms Lymphocytes were isolated from Peyer's patches, the intraepithelial layer, and lamina propria to determine cell yields. Total lymphocyte yield in the Peyer's patches, the intraepithelial layer, and lamina propria decreased with T...Continue Reading

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Citations

Sep 26, 2002·Nutrition·Paul A M van Leeuwen
Jul 1, 1998·Nutrition·K A Kudsk
Feb 16, 2000·Nutrition·S F Abcouwer
Dec 1, 2002·Nutrition Research Reviews·Angel Gil, Ricardo Rueda
Mar 31, 2001·Intensive Care Medicine·R D Griffiths, F Andrews
Jul 27, 2011·The Surgical Clinics of North America·Kazuhiko Fukatsu, Kenneth A Kudsk
Dec 25, 2015·Current Problems in Surgery·Joseph F PierreKenneth A Kudsk
Oct 31, 2007·Gastrointestinal Endoscopy Clinics of North America·Kenneth A Kudsk
Sep 11, 2007·The Journal of Surgical Research·Jiro OmataHidetaka Mochizuki
Feb 14, 2006·Nutrition·Mariana Andrade de OliveiraValbert Nascimento Cardoso
Apr 9, 2001·Clinics in Liver Disease·I S SandhuG T Everson
Apr 27, 2002·American Journal of Surgery·Kenneth A Kudsk
May 20, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Xinying WangKenneth A Kudsk
Sep 18, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Joseph F PierreKenneth A Kudsk
Jul 8, 2000·JPEN. Journal of Parenteral and Enteral Nutrition·P Fürst
Apr 21, 2004·Journal of Pediatric Gastroenterology and Nutrition·S Songül YalçinLevent Oner
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·R D Griffiths
Jan 30, 2002·The American Journal of Clinical Nutrition·Maurizio MuscaritoliFilippo Rossi Fanelli
May 9, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·M AbelyJ F Desjeux
Oct 30, 2001·The Proceedings of the Nutrition Society·R D Griffiths
Jan 15, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·C D Johnson, K A Kudsk

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