PMID: 7932547Sep 30, 1994Paper

"Glycylcyclines". 3. 9-Aminodoxycyclinecarboxamides

Journal of Medicinal Chemistry
T C BardenV J Lee


A series of 9-(acylamino)doxycycline derivatives has been prepared. These analogs exhibit good activity against both tetracycline sensitive and tetracycline resistant Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria that are encoded with the efflux and ribosomal resistance gene factors. N,N-Dialkylglycylamido derivatives possessed the highest activity. Replacement of glycine moiety with other amino acids did not further enhance the activity.


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