Glycylprolyl-p-nitroanilidase in hepatobiliary disease

Clinica Chimica Acta; International Journal of Clinical Chemistry
D R HutchinsonD V Parke

Abstract

The serum activity of glycylprolyl-p-nitroanilidase (GPN) has been compared with isocitrate dehydrogenase and with alanine and aspartate aminotransferases in patients with hepatobiliary diseases, myocardial infarction and chronic inflammatory bowel disease. Serum GPN was markedly increased in all hepatobiliary diseases, especially secondary carcinoma and chronic alcoholic hepatitis, but no abnormal values were seen in patients with chronic inflammatory bowel disease. Slightly elevated GPN activities were noticed in a few cases of myocardial infarction. It is suggested that serum GPN would be useful for monitoring hepatic function, especially in the clinical trials of new drug.

References

Jan 4, 1975·British Medical Journal·P J MartinD M Goldberg
Apr 16, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·J KojimaN Nakamura
Feb 16, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·M HinoS Okuyama
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Apr 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·F WROBLEWSKI, J S LADUE
Oct 1, 1961·Annals of Internal Medicine·N N COHENG N BOWERS

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Citations

Jun 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y MatsumotoG W McCaughan
Apr 8, 2003·World Journal of Gastroenterology : WJG·Run-Zhou NiXian-Yong Meng
Mar 1, 1986·The Journal of Pharmacy and Pharmacology·D R HutchinsonD V Parke
Jan 1, 1988·Journal of Enzyme Inhibition·H U DemuthA Barth

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