Glycyrol exerts potent therapeutic effect on lung cancer via directly inactivating T-LAK cell-originated protein kinase

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Shangyun LuHongbo Hu

Abstract

Molecular targeted therapy for non-small cell lung cancer (NSCLC) has demonstrated promising outcomes. T-lymphokine-activated killer cell-originated protein kinase (TOPK) is found overexpressed in many cancer types such as NSCLC, and is considered to be an effective target for lung cancer treatment. In the present study, we found that glycyrol (GC), a representative coumarin compound isolated from licorice, was highly effective against several human NSCLC cell lines in vitro, and significantly suppressed tumor growth in vivo. Mechanistically, we demonstrated that GC can strongly bind to the TOPK protein and inhibited its kinase activity, leading to the activation of apoptotic signaling pathways. The findings of the present study suggest that GC is a novel promising TOPK inhibitor and this compound deserves to be further investigated for its potential anti-NSCLC activity.

References

Nov 16, 2004·Biochemical and Biophysical Research Communications·Suguru MatsumotoKiyofumi Gyo
Dec 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tatyana A ZykovaZigang Dong
Apr 29, 2009·Journal of Computational Chemistry·Garrett M MorrisArthur J Olson
Nov 11, 2009·Cancer Science·Jae-Hyun ParkToyomasa Katagiri
Apr 24, 2012·Cancer Research·Dong Joon KimZigang Dong
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Jun 29, 2017·Molecular Cancer Therapeutics·Ge GaoZigang Dong
Apr 21, 2018·Nature Reviews. Cancer·Paolo M ComoglioCarla Boccaccio
Jun 16, 2018·Oncogene·Eunmiri RohZigang Dong
Jul 23, 2018·European Journal of Pharmacology·Yeuan Ting LeeChern Ein Oon
Oct 26, 2018·Cell Death & Disease·Katharine J HerbertGeoff S Higgins
Oct 26, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Giacomo PirovanoThomas Reiner

❮ Previous
Next ❯

Citations

Aug 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Geum Seok JeongHoon Kim
Mar 7, 2021·Cells·Ziping HanYumin Luo
Apr 20, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yanbei TuChengwei He
Aug 4, 2021·Toxicon : Official Journal of the International Society on Toxinology·Xiaoyi LiuHongbo Hu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.