Abstract
We analyzed the effects of glycyrrhetinic acid (GA), a licorice compound, on the induction of anoikis-like death and cytoskeletal disruption in the central nervous system (CNS) tumorigenic cells. GA was cytotoxic in time- and dose-dependent manners, and the tumorigenic cells shed floating cells upon the GA treatment and even some of the adherent cells were easily detached from the fibronectin-coated culture dish by gentle shaking and aspiration. Reculture of the detached cells revealed that the longer the duration of GA exposure, the less the number of the proliferatable cells. These results indicate that GA perturbs cell adhesion and induces anoikis-like cell death. Further, GA also induced morphologic changes and disturbed cytoskeletal proteins.
References
Jan 1, 1979·Methods in Enzymology·R G Ham, W L McKeehan
Nov 1, 1979·Experimental Cell Research·J P Mather, G H Sato
Jan 1, 1990·Experimental Cell Research·C RawsonD Barnes
Jun 1, 1989·Journal of Cellular Physiology·D LooD Barnes
Dec 2, 1988·Journal of Chromatography·G de GrootP van Vloten
Apr 10, 1987·Science·D T LooD W Barnes
Sep 1, 1987·Cancer·I W DimeryM J Oswald
Feb 1, 1994·The Journal of Cell Biology·S M Frisch, H Francis
Aug 1, 1993·In Vitro Cellular & Developmental Biology. Animal·T NomuraK Ryoyama
Nov 18, 2000·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·S Shibata
Oct 13, 2001·Molecular Biology of the Cell·D A FlusbergD E Ingber
Oct 10, 2002·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·D ArmaniniM Palermo
Aug 4, 2006·Regulatory Toxicology and Pharmacology : RTP·R A Isbrucker, G A Burdock
Nov 14, 2006·The Journal of Pharmacology and Experimental Therapeutics·Réna G DeschesnesEric Petitclerc
May 3, 2008·Biological & Pharmaceutical Bulletin·Hideaki YamaguchiKazuo Ryoyama
Jul 23, 2008·Biochemical Pharmacology·Marcel N A BijmanEpie Boven
Citations
Sep 2, 2011·The Journal of Biological Chemistry·Hideaki YamaguchiKazuo Ryoyama
Jun 15, 2011·Journal of Molecular Modeling·Hideaki YamaguchiKazuo Ryoyama
May 5, 2011·Biochimie·H YamaguchiK Ryoyama
Jun 6, 2016·Seminars in Cancer Biology·Marc Diederich, Claudia Cerella
Oct 11, 2017·Nutrition and Cancer·Masaru TerasakiMichihiro Mutoh
Dec 17, 2011·Cancer Informatics·Hideaki YamaguchiKazuo Ryoyama
Aug 6, 2021·Oxidative Medicine and Cellular Longevity·Javad Sharifi-RadHafiz Ansar Rasul Suleria