Glycyrrhizic acid ameliorates myocardial ischemic injury by the regulation of inflammation and oxidative state

Drug Design, Development and Therapy
Chongli XuXiaohu Chen

Abstract

Glycyrrhizic acid (GA), a bioactive triterpenoid saponin isolated from the roots of licorice plants (Glycyrrhiza glabra), has been shown to exert a variety of pharmacological activities and is considered to have potential therapeutic applications. The purpose of the present study was to investigate the cardioprotective effect of GA on myocardial ischemia (MI) injury rats induced by isoproterenol (ISO), and explore the potential mechanisms underlying these effects. The rats were randomized into five groups: control, ISO, ISO+diltiazem (10 mg/kg), ISO+GA (10 mg/kg), and ISO+GA (20 mg/kg). Electrocardiogram and histopathological examination were performed. Markers of cardiac marker enzymes (creatine kinase-MB, lactate dehydrogenase), oxidative stress (superoxide dismutase, malondialdehyde [MDA]), and inflammation (TNF-α, IL-1β, and IL-6) were also measured in each group. Proteins involved in NF-κB and Nrf-2/HO-1 pathway were detected by Western blot. GA decreased the ST elevation induced by MI, decreased serum levels of creatine kinase, lactate dehydrogenase, malondialdehyde, IL-6, IL-1β, and TNF-α, and increased serum superoxide dismutase and malondialdehyde activities. Furthermore, GA increased the protein levels of Nrf-2 and HO...Continue Reading

Citations

Feb 7, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Dianna LiuGansheng Zhong
Dec 15, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Xiang WangPeng Zhou
Mar 3, 2020·Journal of Ethnopharmacology·Zecai ZhangNaisheng Zhang
Mar 8, 2019·Journal of Ethnopharmacology·Zecai ZhangNaisheng Zhang
Apr 25, 2021·Phytotherapy Research : PTR·Abu Mohammad SyedBidya Dhar Sahu
May 1, 2021·Biomolecules·Vikram ThakurMunmun Chattopadhyay
May 1, 2021·International Journal of Molecular Sciences·Antonio Rodríguez-SinovasIgnacio Ferreira-González
Nov 7, 2020·Current Vascular Pharmacology·Rasool TavakoliAmirhossein Sahebkar

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
light microscopy
MDA

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