Abstract
Glycyrrhizic acid (GA) is a major active ingredient in licorice. In our study, the effects of GA on acute kidney injury (AKI) in rats and its underlying molecular mechanisms were investigated. The sepsis model was produced by caecal ligation and puncture (CLP) in rats. The molecular and histological experiments were performed in the kidney tissues and serum samples of rats. According to the results obtained, GA alleviated sepsis-induced AKI by improving the pathological changes, decreasing the levels of blood urea nitrogen (BUN), creatinine (Cre), and increasing the survival rate of rats with AKI significantly. The production of inflammatory cytokines, such as TNF-α, IL-1β, and IL-6, was markedly inhibited by GA. Moreover, treatment with GA inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) and expression levels of induced nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in kidney tissues. Furtherly, the apoptosis in kidney tissue induced by AKI was suppressed by GA. Finally, GA could inhibit the activation of NF-κB signaling pathway. Our study suggests that GA alleviates sepsis-induced AKI by inhibiting the NF-κB signaling pathway, which provides a strong evidence for a new approach for treating...Continue Reading
References
Feb 1, 1987·Antiviral Research·M Baba, S Shigeta
Feb 1, 1987·The Journal of Clinical Investigation·C F Nathan
Jan 1, 1982·Microbiology and Immunology·N AbeN Ishida
Apr 15, 1997·Cancer·Y AraseH Kumada
Jan 22, 2000·Journal of the Society for Gynecologic Investigation·D A Kniss
Feb 13, 2001·Trends in Biochemical Sciences·J M Adams, S Cory
Feb 28, 2001·Shock·S AosasaA Matsumoto
Aug 17, 2001·Mutation Research·Y J SurhS S Lee
Oct 9, 2001·Nutrition and Cancer·Z Y Wang, D W Nixon
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patrick N CunninghamRichard J Quigg
Jul 18, 2002·Nephron·Sang Kyung JoNam Hee Won
Oct 9, 2003·Kidney International·Takehiko MiyajiRobert A Star
Jul 7, 2005·American Journal of Physiology. Renal Physiology·Manish M TiwariPhilip R Mayeux
Jul 23, 2005·Anesthesia and Analgesia·Balázs HauserBalasubramanian Venkatesh
Sep 24, 2005·Journal of the American Society of Nephrology : JASN·Glenn M ChertowDavid W Bates
Dec 24, 2005·Shock·William J HubbardIrshad H Chaudry
May 15, 2007·Journal of the American Society of Nephrology : JASN·Liping WuPhilip R Mayeux
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Suzanne HeemskerkRosalinde Masereeuw
Apr 12, 2008·Critical Care : the Official Journal of the Critical Care Forum·Sean M BagshawUNKNOWN ANZICS Database Management Committee
Sep 30, 2009·Nature Reviews. Nephrology·Suzanne HeemskerkPeter Pickkers
Oct 7, 2009·The Journal of Clinical Investigation·Kent DoiRobert A Star
Jul 28, 2010·Emergency Medicine Journal : EMJ·Helen Lindsay CronshawMark Sheils
Sep 15, 2010·Journal of Pharmacological Sciences·Kazumi MoriyukiAtsufumi Kawabata
May 31, 2011·American Journal of Respiratory Cell and Molecular Biology·Min XuZhichao Li
Jun 1, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Rachel Hilton
Jul 1, 2011·The Korean Journal of Internal Medicine·Jay-Wook LeeDong-Jin Oh
Oct 3, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Almut GrenzEric T Clambey
Oct 30, 2012·Journal of Critical Care·Pamela S TiplerCristin A Mount
Nov 3, 2012·Critical Care Research and Practice·Krsto GrozdanovskiKaterina Spasovska
Dec 14, 2012·Nephron. Experimental Nephrology·Sarah J LeeRobyn Cunard
Dec 20, 2012·Anesthesiology·Michael AdamzikMatthias Hartmann
Feb 23, 2013·The Lancet Infectious Diseases·Richard S HotchkissDidier Payen
Aug 28, 2014·International Journal of Molecular Sciences·Shaozhang HouJianzhong Zhang
Citations
Nov 26, 2014·PloS One·Hidetoshi YamadaKen-ichi Kimura
Apr 30, 2015·International Immunopharmacology·Joon-Sung KimSun-Mee Lee
Jun 28, 2016·Fitoterapia·Dawei YuWenbo Liu
Dec 15, 2017·Journal of Diabetes Research·Shaozhang HouXiu Jin
Nov 16, 2016·Stem Cells International·Bing ShenYu Fan
May 10, 2017·BioMed Research International·Feng ZhaoWei Wang
Jul 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Francesco MaioneStefano Pieretti
Dec 17, 2020·Frontiers in Pharmacology·Roodabeh Bahramsoltani, Roja Rahimi
May 25, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chih-Chao YangHon-Kan Yip
Jul 15, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Yao MingHongchun Shen