Abstract
Hypoxia/reoxygenation (H/R) is one of the main causes of coronary artery disease (CAD), which is primarily induced by damage to coronary artery endothelial cells (CAECs). Glycyrrhizic acid (GA) is a natural and abundant pentacyclic triterpenoid glycoside of the licorice root extract, and it has been reported to elicit protective effects against hypoxia, inflammation and apoptosis in ischemic myocardium; therefore, GA may serve as a promising therapeutic agent for ischemia-associated CAD. In the present study, the protective effects of GA against H/R-induced injury in CAECs were investigated. Treatment with GA during H/R maintained cell viability and decreased H/R-induced cell apoptosis in human CAECs. In addition, H/R-mediated induction of intracellular and mitochondrial reactive oxygen species (ROS) was significantly decreased by GA exposure. Similar to ROS scavengers, GA treatment not only exhibited protective effects, but also maintained the mitochondrial membrane potential after H/R and inhibited H/R-induced mitochondrial dysfunction, including deficits in ATP synthesis, mitochondrial DNA copy number and mitochondrial transcriptional activity. Furthermore, GA decreased autophagy/mitophagy, and its protective effect against ...Continue Reading
References
Mar 5, 1999·Science·M Saraste
Feb 24, 2000·The Journal of Pathology·D L Carden, D N Granger
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Apr 18, 2002·Neurobiology of Aging·Francesca BosettiGiancarlo Solaini
Sep 1, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yanmei ZhangQiangyong Jia
Aug 8, 2009·Annual Review of Genetics·Chunxin Wang, Richard J Youle
Oct 20, 2009·Platelets·Xinmin GuoJie Xu
Jul 21, 2010·The American Journal of Cardiology·Aslan T Turer, Joseph A Hill
Dec 6, 2011·PloS One·Hak Jun AhnJong-Soo Lee
Jan 7, 2014·Oxidative Medicine and Cellular Longevity·Yanmei ZhangGanggang Shi
May 21, 2014·Clinical Laboratory·Xueming CaoAihua Chen
Dec 8, 2014·Cell Calcium·Neil W Blackstone
Apr 11, 2015·Circulation Research·Toshiro Saito, Junichi Sadoshima
Jul 3, 2015·Scientific Reports·Yanmei ZhangGanggang Shi
Aug 14, 2015·Journal of the American College of Cardiology·Rodrigo Fernández-JiménezBorja Ibáñez
Dec 15, 2015·British Journal of Pharmacology·Andreas DaiberThomas Münzel
Dec 26, 2015·Cardiovascular Research·Laura Valls-LacalleDavid García-Dorado
Feb 2, 2016·Journal of Cardiovascular Pharmacology·Peng LiuFei Miao
Mar 1, 2016·Biochimica Et Biophysica Acta·Nicolas Tajeddine
Apr 26, 2016·Cell Cycle·Man XuWeijin Zang
May 14, 2016·Free Radical Biology & Medicine·Jian-Kui DuXin Ni
Jun 14, 2016·Journal of Diabetes Research·Mingyan HuFeiyan Yang
Aug 16, 2017·Experimental and Therapeutic Medicine·Xiangna CaiShuying Chen
Jan 27, 2018·Free Radical Biology & Medicine·Susana Cadenas
Jun 1, 2018·Drug Design, Development and Therapy·Chongli XuXiaohu Chen
Aug 11, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Giuseppe ParadiesGiuseppe Petrosillo
Apr 26, 2019·Journal of Thoracic Disease·Paulo Cury RezendeWhady Hueb