Glyoxalase enzyme system in human muscular dystrophy.

Clinica Chimica Acta; International Journal of Clinical Chemistry
N C Kar, C M Pearson

Abstract

Glyoxalase I and glyoxalase II activities were determined in skeletal muscle of control subjects and of patients with Duchenne dystrophy, other major forms of muscular dystrophies and certain neuromuscular disorders. The glyoxalase I activity was normal in all diseases examined except in Duchenne and limb girdle types of muscular dystrophy, where it showed a significant moderate decrease. The glyoxalase II activity in normal human muscle was very low, and the activity was unaltered in muscle of patients with Duchenne and other major forms of muscular dystrophies and spinal muscular atrophy. The selective decrease of glyoxalase I activity in recessively inherited muscular dystrophies may have some relevance to some phases of these disease processes.

References

Jan 1, 1973·Journal of Bioenergetics·A Szent-Györgyi
May 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·L G EgyüdA Szent-Györgyi
Feb 3, 1967·Science·A Szent-GyörgyiJ A McLaughlin
Jul 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·L G Együd, A Szent-Györgyi
May 1, 1954·The Journal of Clinical Investigation·J C DREYFUSF SCHAPIRA

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Citations

Jan 1, 1993·Molecular Aspects of Medicine·P J Thornalley
Sep 27, 2018·Frontiers in Cardiovascular Medicine·Jacob T Mey, Jacob M Haus

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