Glyoxalase I drives epithelial-to-mesenchymal transition via argpyrimidine-modified Hsp70, miR-21 and SMAD signalling in human bronchial cells BEAS-2B chronically exposed to crystalline silica Min-U-Sil 5: Transformation into a neoplastic-like phenotype

Free Radical Biology & Medicine
C AntognelliV N Talesa

Abstract

Glyoxalase I (Glo1) is the main scavenging enzyme of methylglyoxal (MG), a potent precursor of advanced glycation end products (AGEs). AGEs are known to control multiple biological processes, including epithelial to mesenchymal transition (EMT), a multistep phenomenon associated with cell transformation, playing a major role in a variety of diseases, including cancer. Crystalline silica is a well-known occupational health hazard, responsible for a great number of human pulmonary diseases, such as silicosis. There is still much debate concerning the carcinogenic role of crystalline silica, mainly due to the lack of a causal demonstration between silica exposure and carcinogenesis. It has been suggested that EMT might play a role in crystalline silica-induced lung neoplastic transformation. The aim of this study was to investigate whether, and by means of which mechanism, the antiglycation defence Glo1 is involved in Min-U-Sil 5 (MS5) crystalline silica-induced EMT in BEAS-2B human bronchial epithelial cells chronically exposed, and whether this is associated with the beginning of a neoplastic-like transformation process. By using gene silencing/overexpression and scavenging/inhibitory agents, we demonstrated that MS5 induced hyd...Continue Reading

References

Oct 16, 1999·The Journal of Biological Chemistry·M DingV Vallyathan
Feb 1, 2000·Journal of Cellular Physiology·T Scholzen, J Gerdes
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
May 16, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Alina DeshpandeBruce E Lehnert
Sep 13, 2002·The Journal of Biological Chemistry·Hiroshi SakamotoTakashi Tsuruo
Jul 19, 2005·Cancer Research·Jennifer A ChanKenneth S Kosik
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Jean Paul Thiery, Jonathan P Sleeman
May 23, 2006·Current Molecular Medicine·Takashi SatoMasayoshi Takeuchi
Jun 10, 2008·Developmental Cell·Jing Yang, Robert A Weinberg
Nov 8, 2008·American Journal of Respiratory Cell and Molecular Biology·Manasi N ShuklaPrabir Ray
Oct 24, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Jorina GeysPeter H M Hoet
Dec 1, 2009·Cell·Jean Paul ThieryM Angela Nieto
Jan 16, 2010·Journal of Toxicology and Environmental Health. Part a·Maureen R GwinnVal Vallyathan
Jan 20, 2010·The International Journal of Biochemistry & Cell Biology·Norbert NassAndreas Simm
Jul 21, 2010·The Journal of Experimental Medicine·Gang LiuEdward Abraham
Oct 22, 2010·Amino Acids·Naila Rabbani, Paul J Thornalley
Dec 9, 2010·Cancer Biology & Therapy·Xuan PanRui Wang
Jan 20, 2011·Nature Reviews. Genetics·Eric Huntzinger, Elisa Izaurralde
Jun 15, 2011·Carcinogenesis·Jin-Yuan Shih, Pan-Chyr Yang
Sep 17, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Eileen L HeinrichSteven M Dubinett
Mar 9, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephen P MalkoskiXiao-Jing Wang
Mar 29, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Mitsuo SatoYoshinori Hasegawa
Nov 3, 2012·Molecular & Cellular Proteomics : MCP·Sneha B BansodeMahesh J Kulkarni
Dec 5, 2012·The Journal of Toxicological Sciences·Wang FaxuanLan Yajia
Jan 22, 2013·The International Journal of Biochemistry & Cell Biology·Cinzia AntognelliVincenzo Nicola Talesa

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Citations

Jun 4, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Cristina PavanBice Fubini
Feb 1, 2018·International Journal of Molecular Sciences·Cinzia Antognelli, Vincenzo Nicola Talesa
Mar 6, 2018·Journal of Cellular and Molecular Medicine·Cinzia AntognelliVincenzo N Talesa
Jun 9, 2019·Cells·Cinzia AntognelliVincenzo N Talesa
Sep 11, 2020·International Journal of Radiation Biology·Cinzia AntognelliCynthia Aristei
Mar 19, 2021·Experimental Biology and Medicine·Chamithi Karunanayake, Richard C Page

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