Glyphosate affects swine ovarian and adipose stromal cell functions

Animal Reproduction Science
Paolo GiganteGiuseppina Basini

Abstract

Although Glyphosate (GLY) is a widely used pesticide, its effects on ovarian function and stem cell differentiation are still largely unknown. Therefore, as a contribution on this subject, the present work reports an investigation of the in vitro effects of GLY on swine granulosa cells and adipose stromal cells (ASCs). The effect of GLY at different doses (0.2, 4 and 16 μg/mL) was evaluated on granulosa cells growth (BrDU incorporation and ATP production), steroidogenesis (17-β estradiol and progesterone secretion) and redox status (superoxide and nitric oxide production and non-enzymatic scavenging activity). GLY has been shown to inhibit cell growth, 17-β estradiol and non-enzymatic scavenging activity and to increase progesterone and nitric oxide secretion (P < 0.05). In addition, GLY significantly decreased the viability of ASCs (P < 0.001), and inhibited their adipogenic differentiation. These data indicate that GLY alters the main features of granulosa cells and ASCS thus suggesting that GLY could affect both reproductive function and adipose tissues homeostasis.

Citations

Nov 2, 2019·Reproduction, Fertility, and Development·R CiccimarraG Basini
Jul 21, 2020·Scientific Reports·Marcella SpinaciGiovanna Galeati
Dec 14, 2019·Environmental Science and Pollution Research International·Ana Paola Balderrama-CarmonaEdgar Felipe Morán-Palacio
Jan 13, 2021·Animals : an Open Access Journal From MDPI·Fausto QuintavallaRoberto Ramoni
Nov 3, 2020·Chemosphere·Juan P MuñozGloria M Calaf
Dec 9, 2020·Domestic Animal Endocrinology·G BasiniF Grasselli
Mar 5, 2021·Domestic Animal Endocrinology·G BasiniF Grasselli
Apr 2, 2021·Frontiers in Endocrinology·Anderson Tadeu de Araújo-RamosAnderson Joel Martino-Andrade
Jul 14, 2020·Molecular and Cellular Endocrinology·Paola IngaramoEnrique H Luque
Nov 26, 2019·Theriogenology·Alessia PacentraGiuseppina Basini
May 18, 2021·Pesticide Biochemistry and Physiology·Changwon YangGwonhwa Song
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Francesca GrasselliGiuseppina Basini
Jul 27, 2021·Frontiers in Endocrinology·María Mercedes MilesiJorgelina Varayoud
Jul 9, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Virginia LorenzMaría M Milesi
Aug 24, 2021·The Science of the Total Environment·Pablo RuizVicent Yusà
Jan 7, 2022·Annual Review of Pharmacology and Toxicology·Xiaojing WangMaría-Aránzazu Martínez

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