Glyphosate-based herbicides modulate oxidative stress response in the nematode Caenorhabditis elegans

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
María Florencia KronbergEliana Munarriz

Abstract

Glyphosate-based formulation is used as non-selective and post-emergent herbicides in urban and rural activities. In view of its recurring applications in agricultural producing countries, the increase of glyphosate concentration in the environment stresses the need to test the adverse effects on non-target organisms and assess the risk of its use. This paper analyzes the toxicological and oxidative stress and modulatory effects of a glyphosate commercial formulation (glyphosate F) on the nematode Caenorhabditis elegans. We detected ROS production and enhancement of oxidative stress response in glyphosate F-treated nematodes. Particularly, we found an increased ctl-1 catalase gene expression of a catalase specific activity. In addition, we showed that glyphosate F treatment activated the FOXO transcription factor DAF-16, a critical target of the insulin/IGF-1 signaling pathway, which modulates the transcription of a broad range of genes involved in stress resistance, reproductive development, dauer formation, and longevity. In summary, the exposure of glyphosate F induces an oxidative imbalance in C. elegans that leads to the DAF-16 activation and consequently to the expression of genes that boost the antioxidant defense system...Continue Reading

Citations

May 18, 2019·Journal of Endocrinological Investigation·S E MeshkaniH Hosseinzadeh
Aug 30, 2020·Ecotoxicology and Environmental Safety·Jiechen YinYuanqing Bu
May 18, 2020·Environmental Pollution·Yunjiang YuMingdeng Xiang
Oct 28, 2019·Ecotoxicology and Environmental Safety·Ana De la Parra-Guerra, Jesus Olivero-Verbel
Jan 7, 2022·Annual Review of Pharmacology and Toxicology·Xiaojing WangMaría-Aránzazu Martínez

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