Glyphosate herbicide formulation: a potentially lethal ingestion

Emergency Medicine Australasia : EMA
Julian Stella, Matthew Ryan

Abstract

Glyphosate surfactant herbicide (GlySH) toxicity is an uncommon poisoning. We report two fatalities involving suicidal ingestion of this herbicide. Both deaths occurred despite early recognition of the serious nature of the poisoning and aggressive treatment. The deaths in this series are analysed in the context of a review of existing literature. Although traditionally regarded as minimally toxic, many deaths have been reported following suicidal ingestion. Severe GlySH toxicity may be refractory even to the most intensive supportive care. The triad of pulmonary oedema, metabolic acidosis and hyperkalaemia portends poor outcome. While containing a carbon phosphorus moiety, GlySH does not exhibit organophosphate toxicity. A clinical guide to assessing severity of GlySH toxicity is proposed and treatment modalities discussed.

References

Jan 1, 1991·Human & Experimental Toxicology·A R TalbotT R Sanford
Mar 1, 1991·Human & Experimental Toxicology·D B MenkesI R Edwards
Jan 1, 1991·Journal of Toxicology. Clinical Toxicology·R L TominackJ F Deng
Feb 20, 1988·Lancet·J R Jackson
May 1, 1997·The Journal of Surgical Research·Z YuJ D Ellenhorn
Jun 15, 2000·Regulatory Toxicology and Pharmacology : RTP·G M WilliamsI C Munro
Aug 25, 2000·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·H L LeeL M Tsai
Jan 1, 2003·Journal of Toxicology. Clinical Toxicology·Daniel A GoldsteinDonna R Farmer

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Citations

Jun 7, 2005·The Science of the Total Environment·Maria Celina Piazza RecenaEloisa Dutra Caldas
Jan 31, 2009·Journal of Occupational Medicine and Toxicology·Chirn-Bin Chang, Chia-Chu Chang
Nov 3, 2009·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Olivera PotrebićMisel Radulac
Jun 11, 2014·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Kranthi MahendrakarDnyaneshwar P Mutkule
Sep 21, 2010·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Jeong Mi Moon, Byeong Jo Chun
Jun 6, 2006·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Jeong Mi MoonByeong Jo Chun
Feb 9, 2010·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Darren M RobertsAndrew H Dawson
Aug 12, 2009·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Hsin-Ling LeeHow-Ran Guo
Jan 8, 2013·Forensic Science International : Synergy·K ZouaouiG Lachâtre
Jul 8, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Hui-Young LeeSook-Won Ryu
Mar 25, 2008·The American Journal of Emergency Medicine·Cheng-ting HsiaoShih-hsin Hsiao
Mar 25, 2008·The American Journal of Emergency Medicine·Ching-Hsing LeeChih-Chuan Lin
Sep 27, 2005·The Journal of Emergency Medicine·Michael J Matteucci, Richard F Clark
Jun 12, 2016·Acta histochemica·Pengyuan DaiChunmei Li
Jun 4, 2008·Journal of Computer Assisted Tomography·Luca Saba, Giorgio Mallarini
Aug 11, 2006·Journal of Environmental Quality·Antonio L Cerdeira, Stephen O Duke
Jul 28, 2012·The American Journal of Forensic Medicine and Pathology·Pongruk SribanditmongkolPiya Durongkadech
Apr 13, 2017·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·J IndirakshiV Siva Kumar
Jan 26, 2021·The American Journal of Forensic Medicine and Pathology·Jessica A BignerJulie M Teuber

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