Glyphosate-surfactant herbicide-induced reversible encephalopathy

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
R C MalhotraR G Beran

Abstract

Glyphosate-surfactant (GlySH) is a commonly used herbicide that has been used in attempted suicide. Most reports of GlySH toxicity in patients have followed ingestion of the commercial product "Round-up" (Monsanto Ltd; Melbourne, Victoria, Australia), which consists of a mixture of glyphosate (as a isopropylanine salt) and a surfactant (polyoxyethyleneamine). Ingestion of Round-up is reported to cause significant toxicity including nausea, vomiting, oral and abdominal pain. Renal and hepatic impairment and pulmonary oedema may also occur. Impaired consciousness and encephalopathy have been reported as sequelae but there are limited data on the central nervous system (CNS) effects of Round-up toxicity. We report a 71-year-old male who attempted suicide with GlySH and developed a prolonged but reversible encephalopathy suggestive of acute CNS toxicity.

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Citations

Mar 5, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Chie SatoToshimitsu Ide
Mar 4, 2011·Parkinsonism & Related Disorders·Gang WangSheng-Di Chen
Sep 15, 2015·The Science of the Total Environment·Francesca CaloniFranca Davanzo
Feb 22, 2014·Lancet Neurology·Philippe Grandjean, Philip J Landrigan
Jun 20, 2014·Lancet Neurology·Daniel A Goldstein, David A Saltmiras
Aug 30, 2017·Frontiers in Behavioral Neuroscience·Yassine Ait BaliMohamed Bennis
Mar 24, 2021·Environment International·Samuel FuhrimannAna M Mora
Aug 7, 2021·Neuropsychopharmacology Reports·Saaya YokoyamaKazutaka Shimoda

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