GM-CSF expression is preferential to multi-CSF (IL-3) expression in murine T lymphocyte clones.

Growth Factors
N M Gough, A Kelso

Abstract

The expression of the lymphokines GM-CSF and Multi-CSF (IL-3) has been studied in three IL-2-dependent CD4+ T lymphocyte clones. By contrast with the widely held view that lymphokine genes are coordinately expressed, the present study revealed a marked preference for GM-CSF compared with Multi-CSF expression. Preferential expression of GM-CSF was evident in a number of situations: early after stimulation via the T cell antigen receptor; in a proportion of low-producing cells of a clone; and in response to IL-2. There was a clear hierarchy of the three clones studied, each being ranked in the same order in all situations, suggesting that a common mechanism underlies each phenomenon. The possibility that the GM-CSF gene is responsive to lower doses of intercellular signal than the Multi-CSF gene was rendered unlikely, since in only one clone was GM-CSF preferentially expressed at low doses of stimulus. Since GM-CSF expression occurred more rapidly after stimulation, the possibility that Multi-CSF expression is dependent upon that of GM-CSF was considered. However, GM-CSF production was neither necessary nor sufficient for Multi-CSF expression: A retroviral construct expressing a GM-CSF cDNA was introduced into one of the clones, ...Continue Reading

References

Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A Kelso, N M Gough
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Citations

Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·E I FrolovaM Dean
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A B Troutt, A Kelso
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D MetcalfM Li
Feb 3, 1998·Transplantation·D R Fitzpatrick, A Kelso
Dec 14, 2011·International Journal of Immunogenetics·S ThennarasuG Dhinakar Raj

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