GM haplotype diversity of 82 populations over the world suggests a centrifugal model of human migrations

American Journal of Physical Anthropology
J M DugoujonA Sanchez-Mazas


This study investigates the GM genetic relationships of 82 human populations, among which 10 represent original data, within and among the main broad geographic areas of the world. Different approaches are used: multidimensional scaling analysis and test for isolation by distance, to assess the correlation between genetic variation and spatial distributions; analysis of variance, to investigate the genetic structure at different hierarchical levels of population subdivision; genetic similarity map (geographic map distorted by available genetic information), to identify regions of high and low genetic variation; and minimal spanning network, to point out possible migration routes across continental areas. The results show that the GM polymorphism is characterized by one of the highest amounts of genetic variation observed so far among populations of different continents (Fct=0.3915, P < 0.0001). GM diversity can be explained by a model of isolation by distance (IBD) at most continental levels, with a particularly significant fit to IBD for the Middle East and Europe. Five peripheral regions of the world (Europe, west and south sub-Saharan Africa, Southeast Asia, and America) exhibit a low level of genetic diversity both within a...Continue Reading


Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·Guido Barbujani, R R Sokal
Feb 1, 1988·Human Genetics·A Sanchez-Mazas, A Langaney
Jan 1, 1985·American Journal of Physical Anthropology·R C WilliamsT A Burch
Dec 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·G N Vyas, H H Fudenberg
Mar 1, 1972·Theoretical Population Biology·W J Ewens
Nov 1, 1973·American Journal of Physical Anthropology·A G Steinberg
Jan 1, 1984·Vox Sanguinis·E van LoghemH Matsumoto
Apr 1, 1993·American Journal of Physical Anthropology·S M Callegari-JacquesP Maurieres
Oct 1, 1994·American Journal of Physical Anthropology·Guido BarbujaniC Renfrew
May 1, 1996·Annals of Human Biology·F CalafellA Piazza
Mar 1, 1997·American Journal of Physical Anthropology·T M KarafetM F Hammer
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·Guido BarbujaniL Luca Cavalli-Sforza
Jul 1, 1997·American Journal of Human Genetics·L Luca Cavalli-Sforza, E Minch
Oct 27, 1997·American Journal of Human Genetics·E WatsonH J Bandelt
Dec 18, 1997·American Journal of Human Genetics·S L Bonatto, F M Salzano
Apr 16, 1998·American Journal of Human Genetics·Guido BarbujaniLounes Chikhi
Apr 29, 1998·Molecular Biology and Evolution·M F HammerS L Zegura
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·Lounes ChikhiGuido Barbujani
Mar 3, 1999·American Journal of Human Genetics·T M KarafetM F Hammer
Dec 2, 1999·Nature Genetics·L Quintana-MurciA S Santachiara-Benerecetti
Jan 13, 2000·American Journal of Human Genetics·L SimoniGuido Barbujani
Apr 14, 2000·American Journal of Human Genetics·M T Hamblin, A Di Rienzo
Nov 4, 2000·Nature Genetics·Peter A UnderhillP J Oefner
Nov 9, 2000·Current Biology : CB·M KayserM Stoneking
Dec 29, 2000·Nature·M IngmanU Gyllensten
Jan 3, 2001·Proceedings of the National Academy of Sciences of the United States of America·Guido Barbujani, G Bertorelle
Jun 21, 2001·Annals of Human Genetics·Peter A UnderhillL Luca Cavalli-Sforza
Jun 23, 2001·Molecular Biology and Evolution·M F HammerS L Zegura
Aug 30, 2001·Proceedings of the National Academy of Sciences of the United States of America·R S WellsW F Bodmer
Sep 11, 2001·Experimental and Clinical Immunogenetics·J P PandeyM A Dooley
Dec 4, 2001·American Journal of Human Genetics·Jeffrey T LellDouglas C Wallace
Jan 5, 2002·Human Biology·A Sanchez-MazasA Langaney
Jan 10, 2002·European Journal of Human Genetics : EJHG·P DardA Sanchez-Mazas
Mar 8, 2002·Nature·Alan Templeton
Mar 23, 2002·American Journal of Human Genetics·Fulvio CrucianiPeter A Underhill
Apr 16, 2002·American Journal of Human Genetics·Eduardo Tarazona-Santos, Fabrício R Santos
Aug 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Lounes ChikhiMark A Beaumont
Sep 27, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Yoko Satta, Naoyuki Takahata
Jan 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Dan MishmarDouglas C Wallace
Feb 18, 1961·Nature·C ROPARTZL RIVAT
Jun 1, 1975·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·A PrevostiG Alonso
Mar 1, 1969·Evolution; International Journal of Organic Evolution·C Clark Cockerham
Nov 1, 1984·Evolution; International Journal of Organic Evolution·B S Weir, C Clark Cockerham


Dec 3, 2014·Comptes rendus biologies·César Fortes-LimaR Calderón
Dec 4, 2012·Comptes rendus biologies·Nicolas BrucatoJ M Dugoujon
Aug 14, 2012·Human Immunology·J P PandeyS Tsugane
May 8, 2010·Human Immunology·Daniele CatanzaroMichel Toungouz-Nevessignsky
May 9, 2008·American Journal of Human Biology : the Official Journal of the Human Biology Council·Moses S SchanfieldJoan C Stevenson
Apr 13, 2011·Immunology·A Sanchez-MazasErik Thorsby
Dec 16, 2011·International Journal of Immunogenetics·M CapredonJ-M Dugoujon
Jan 16, 2010·MAbs·Roy Jefferis, Marie-Paule Lefranc
Sep 29, 2011·Molecular Immunology·Andrew M GoetzeGregory C Flynn
Dec 10, 2016·Transfusion·Donald R Branch, Connie M Westhoff
Mar 8, 2017·Molecular & Cellular Proteomics : MCP·Magalie DambrunFlorence Migot-Nabias
Jun 15, 2007·American Journal of Physical Anthropology·E E MarchaniD H O'Rourke
Dec 27, 2005·American Journal of Human Biology : the Official Journal of the Human Biology Council·C CoudrayJ M Dugoujon
Sep 26, 2020·Frontiers in Immunology·Annmaree K Warrender, William Kelton
May 22, 2020·Frontiers in Immunology·Steven W de TaeyeGestur Vidarsson
Jun 16, 2010·Annals of Human Biology·S FrigiA Ben Ammar-Elgaaied
Dec 20, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·David TernantValérie Gouilleux-Gruart
Aug 26, 2018·European Journal of Human Genetics : EJHG·Florence PetitCaroline Costedoat
Jul 7, 2017·JCI Insight·Heather L HowieJames C Zimring

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Related Papers

Nucleic Acids Research
Marie-Paule LefrancPatrice Duroux
American Journal of Human Biology : the Official Journal of the Human Biology Council
Moses S SchanfieldJoan C Stevenson
© 2021 Meta ULC. All rights reserved