PMID: 9545780Apr 18, 1998Paper

GM1-gangliosidosis knockout mouse

No to hattatsu. Brain and development
A Oshima

Abstract

We generated a beta-galactosidosis mouse by gene targeting in an embryonic stem cell. Clinical, pathological, and biochemical analyses revealed that this mouse is a useful animal model to study the pathogenesis and therapy of human GM1-gangliosidosis.

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Related Papers

British Journal of Haematology
Jiri PavluNicki Panoskaltsis
[Hokkaido igaku zasshi] The Hokkaido journal of medical science
T Orii
© 2022 Meta ULC. All rights reserved