GM1 increases the content and mRNA of NGF in the brain of aged rats

Neuroreport
Anne-Marie DucheminM Hadjiconstantinou

Abstract

Aged (20-22 months old) and young (3 months old) Sprague-Dawley rats were treated with GM1 ganglioside, 30 mg/kg i.p. for 30 days, and the content of nerve growth factor (NGF) and the high-affinity tyrosine receptor kinase (Trk) examined. NGF, estimated by a two-site enzyme immunoassay, was found moderately decreased in the frontal cortex and hippocampus, but not in the striatum of aged animals compared with young animals. The NGF decrease was accompanied by a reduction of NGF mRNA, evaluated by northern blot. Trk protein, determined by western blot with a pan-Trk antibody, was not altered in any region studied in the aged brain. GM1 treatment partially restored NGF and NGF mRNA in frontal cortex and hippocampus in the aged brain, but treatment had no effect on Trk protein. GM1 did not modify any of the parameters investigated in young animals.

References

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Citations

Nov 7, 2009·Naunyn-Schmiedeberg's Archives of Pharmacology·Ana Flávia FurianCarlos Fernando Mello
Mar 19, 1999·European Journal of Pharmacology·G M CunhaG S Viana
Jan 5, 2002·Neurobiology of Aging·A K Dickason, L G Isaacson
Oct 25, 2000·Neuroscience Letters·F G VarolM Hadjiconstantinou
Jun 18, 2002·Journal of Neurochemistry·Anne-Marie DucheminMaria Hadjiconstantinou
Jun 28, 2003·Neurotoxicity Research·Alessia BachisItalo Mocchetti
Oct 26, 2010·Neuropharmacology·Seung T LimItalo Mocchetti
Oct 7, 2008·Neurochemistry International·Ana Flávia FurianCarlos Fernando Mello
Aug 9, 2005·Brain Research·Lili MoMaria Hadjiconstantinou
Feb 5, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ke WuEdwin M Meyer

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