GM6 Attenuates Alzheimer's Disease Pathology in APP Mice

Molecular Neurobiology
Jin YuMark S Kindy

Abstract

Alzheimer's disease (AD) results in the deposition of amyloid β (Aβ) peptide into amyloid fibrils and tau into neurofibrillary tangles. Regardless of whether or not these entities are a cause or consequence of the disease process, preventing their accumulation or accelerating their clearance may slow the rate of AD onset. Motoneuronotrophic factor (MNTF) is an endogenous neurotrophin that is specific for the human nervous system, and some of the observed effects of MNTF include motoneuron differentiation, maintenance, survival, and reinnervation of target muscles and organs. GM6 is a six-amino-acid component of MNTF that appears to replicate its activity spectrum. In this study, we investigated the effect of GM6 in a mouse model of AD before the development of amyloid plaques and determined how this treatment affected the accumulation of Aβ peptide and related pathologic changes (e.g., inflammation, nerve growth factor (NGF) expression, cathepsin B, and memory impairment). Application of GM6 over a 4-month period in young APP/ΔPS1 double-transgenic mice resulted in attenuation in Aβ peptide levels, reduction of inflammation and amyloid load, increased cathepsin B expression, and improved spatial orientation. In addition, treatm...Continue Reading

References

Oct 1, 1991·Trends in Pharmacological Sciences·J Hardy, D Allsop
Jun 13, 2000·Alzheimer Disease and Associated Disorders·H AkiyamaK Ikeda
Feb 13, 2001·Current Opinion in Cell Biology·M L Garcia, D W Cleveland
Feb 9, 2007·Journal of Neurochemistry·Dominic M Walsh, Dennis J Selkoe
Jun 7, 2007·Nature Reviews. Neuroscience·Frank M LaFerlaSalvatore Oddo
Apr 12, 2008·The American Journal of Pathology·Salim S El-AmouriMark S Kindy
Jul 11, 2009·Expert Opinion on Investigational Drugs·Bruno P Imbimbo
Jan 14, 2010·Neuromolecular Medicine·Reisa A SperlingKeith A Johnson
Jan 29, 2010·The New England Journal of Medicine·Henry W Querfurth, Frank M LaFerla
Jun 19, 2010·The New England Journal of Medicine·Richard Mayeux
Oct 3, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew ElvingtonStephen Tomlinson
Nov 6, 2012·Cold Spring Harbor Perspectives in Medicine·David M HoltzmanDennis J Selkoe
Nov 13, 2015·Expert Opinion on Therapeutic Patents·Haifan WuJianfeng Cai
Jan 2, 2016·Pharmacological Reports : PR·Justyna GodyńBarbara Malawska
Mar 31, 2016·EMBO Molecular Medicine·Dennis J Selkoe, John Hardy
Nov 1, 2016·Journal of Neurochemistry·Eric Karran, Bart De Strooper
Jun 18, 2016·Journal of Alzheimer's Disease : JAD·Ingar Olsen, Sim K Singhrao
Jul 20, 2017·Journal of Biomedical Science·Shih-Ya Hung, Wen-Mei Fu
Jun 1, 2018·Brain : a Journal of Neurology·Harald HampelZaven S Khachaturian

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Citations

Jan 13, 2021·International Journal of Molecular Sciences·Jin YuMark S Kindy

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Datasets Mentioned

BETA
GM6

Methods Mentioned

BETA
ELISA
enzyme-linked immunosorbent assay

Software Mentioned

Image Analysis

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