GNG5 is a novel oncogene associated with cell migration, proliferation, and poor prognosis in glioma.

Cancer Cell International
Wang ZhangZhiguo Lin

Abstract

Although many biomarkers have been reported for detecting glioma, the prognosis for the disease remains poor, and therefore, new biomarkers need to be identified. GNG5, which is part of the G-protein family, has been associated with different malignant tumors, though the role of GNG5 in glioma has not been studied. Therefore, we aimed to identify the relationship between GNG5 and glioma prognosis and identify a new biomarker for the diagnosis and treatment of gliomas. We used data on more than a thousand gliomas from multiple databases and clinical data to determine the expression of GNG5 in glioma. Based on clinical data and CGGA database, we identified the correlation between GNG5 and multiple molecular and clinical features and prognosis using various analytical methods. Co-expression analysis and GSEA were performed to detect GNG5-related genes in glioma and possible signaling pathways involved. ESTIMATE, ssGSEA, and TIMER were used to detect the relationship between GNG5 and the immune microenvironment. Functional experiments were performed to explore the function of GNG5 in glioma cells. GNG5 is highly expressed in gliomas, and its expression level is positively correlated with pathological grade, histological type, age, ...Continue Reading

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Software Mentioned

TIMER
Graphpad Prism
ssGSEA
R
ESTIMATE
limma
ImageProPlus
ImageJ
GEPIA
GSEA

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