GnRH agonist protocol administration in the luteal phase in ICSI-ET cycles stimulated with the long GnRH agonist protocol: a randomized, controlled double blind study

Human Reproduction
B AtaB Urman

Abstract

GnRH agonist administration in the luteal phase was reported to beneficially affect the clinical outcome of intracytoplasmic sperm injection (ICSI) and embryo transfer (ET) cycles. This double blind, randomized, placebo controlled trial evaluates whether a single dose GnRH agonist administered 6 days after ICSI increases ongoing pregnancy rates following ET in cycles stimulated with the long GnRH agonist protocol. Five hundred and seventy women undergoing ET following controlled ovarian stimulation with a long GnRH agonist protocol were included. In addition to routine luteal phase support with progesterone, women were randomized to receive a single 0.1 mg dose of triptorelin or placebo 6 days after ICSI. Randomization was done on the day of ET according to a computer generated randomization table. Ongoing pregnancy rate beyond 20th week of gestation was the primary outcome measure. The trial was powered to detect a 12% absolute increase from an assumed 38% ongoing pregnancy rate in the placebo group, with an alpha error level of 0.05 and a beta error level of 0.2. There were 89 (31.2%) ongoing pregnancies in the GnRH agonist group, and 84 (29.5%) in the control group (absolute difference +1.7%, 95% confidence interval -5.8% to...Continue Reading

Citations

Mar 6, 2009·Current Opinion in Obstetrics & Gynecology·Mohamed Aboulghar
Sep 10, 2010·Reproductive Biology and Endocrinology : RB&E·João Batista A OliveiraJosé G Franco
Mar 28, 2013·Journal of Human Reproductive Sciences·Dattaprasad B Inamdar, Abha Majumdar
Sep 23, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Gülşah Aynaoğlu YıldızRuşen Aytaç
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Apr 10, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·W P MartinsC O Nastri

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