GnRH analog, leuprorelin acetate, promotes regeneration of rat spermatogenesis after severe chemical damage

International Journal of Urology : Official Journal of the Japanese Urological Association
Koichi UdagawaM Hosaka

Abstract

Future fertility is a major concern for cancer patients who undergo intensive chemotherapy. There has been controversy about whether hormonal treatments may have protective effects against the severe spermatogenic damage caused by chemotherapy or irradiation. Recently, it has been proposed that gonadotrophin-releasing hormone (GnRH) analogs administered after testicular damage stimulate the recovery of spermatogenesis. In this study, we have investigated the effects of GnRH agonist, leuprorelin, on the damage to spermatogenesis induced by busulfan. Fisher rats were treated with busulfan, 25 mg/kg, intraperitoneally. The effects of subcutaneous injections of leuprorelin before or after treatment were evaluated histologically 18 weeks later. The percentage of 'recovered' seminiferous tubules was 27.7 +/- 12.6% in control rats without leuprorelin and 26.9 +/- 10.2% in rats with leuprorelin injected 4 weeks before busulfan. Rats in both groups showed poor recovery of spermatogenesis with an increase of intratesticular fluid. However, rats treated with leuprorelin three times (4 weeks apart) after busulfan showed an improvement of up to 56.5 +/- 12.0% (P < 0.05). A focal but massive necrotic lesion in the testis was observed only in...Continue Reading

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Citations

Jun 30, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Gensheng WangMarvin L Meistrich
Jun 3, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Marvin L Meistrich, Gunapala Shetty
Jul 19, 2008·International Journal of Andrology·Samara Urban de Oliva, Sandra Maria Miraglia
May 21, 2003·International Journal of Andrology·Marvin L Meistrich, Gunapala Shetty
Feb 14, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Takehiko Ogawa
Aug 15, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Koichi UdagawaYoshinobu Kubota
Mar 17, 2010·Hematological Oncology·Marleen A E van der KaaijHanneke C Kluin-Nelemans
Dec 3, 2014·Fertility and Sterility·Roberto Benavides-GarciaBrian P Hermann
Feb 2, 2018·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·O Yaman, Y Topcu-Tarladacalisir
Jul 23, 2013·Clinical and Experimental Reproductive Medicine·Heejun ChiSungil Roh
Jun 11, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Leandra Campos LirdiSandra Maria Miraglia
May 3, 2014·Journal of Toxicologic Pathology·Toko OhiraToru Hoshiya
Apr 11, 2014·Iranian Red Crescent Medical Journal·Mehri MirhoseiniJavad Mohammadi Asl
Nov 25, 2005·Endocrinology·Karen L PorterMarvin L Meistrich
Mar 14, 2003·Journal of Andrology·Marvin L Meistrich, Gunapala Shetty
Jun 5, 2017·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yi XianGang Li

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