PMID: 11925376Apr 2, 2002Paper

GnRH antagonist in assisted reproduction: a Cochrane review

Human Reproduction
H G Al-Inany, M Aboulghar

Abstract

In the present systematic review, we wished to compare the efficacy of gonadotrophin-releasing hormone (GnRH) antagonist and GnRH agonist administration for controlled ovarian hyperstimulation in assisted conception. Five randomized controlled trials fulfilled the inclusion criteria. In four studies, the multiple low-dose (0.25 mg) antagonist regimen was applied and, in one study, the single high-dose (3 mg) antagonist regimen was investigated. In all trials, reference treatment included a long protocol of GnRH agonist (buserelin, leuprorelin or triptorelin) starting in the mid-luteal phase of the preceding cycle. In comparison with the long protocol of GnRH agonist, the overall odds ratio for the prevention of premature LH surges was 1.76 [95% confidence interval (CI) 0.75-4.16], which was not statistically significant. There were significantly fewer clinical pregnancies in those treated with GnRH antagonists (OR 0.79; 95% CI 0.63-0.99). There was no statistically significant reduction in incidence of severe ovarian hyperstimulation syndrome between the two regimens (relative risk 0.51; OR 0.79; 95% CI 0.22-1.18). We concluded that the fixed GnRH antagonist protocol is a short and simple protocol with good clinical outcome, bu...Continue Reading

Citations

Apr 10, 2009·Archives of Gynecology and Obstetrics·Razieh Dehghani FirouzabadiRobab Davar
Apr 10, 2010·Archives of Gynecology and Obstetrics·Ensieh Shahrokh TehraninejadMarzieh Ataie
May 28, 2013·Archives of Gynecology and Obstetrics·Mustafa KaraBetul Ozdemir
Jun 21, 2006·Journal of Assisted Reproduction and Genetics·Kyono KoichiSasaki Sachiko
Jul 11, 2006·Journal of Assisted Reproduction and Genetics·Robert MedvedTomaz Tomazevic
Jul 26, 2006·Journal of Assisted Reproduction and Genetics·Heng-Ju ChenChii-Ruey Tzeng
Dec 1, 2007·Journal of Assisted Reproduction and Genetics·Porntip SirayapiwatSomchai Niruthisard
Jul 10, 2013·Journal of Assisted Reproduction and Genetics·J BarcroftK J Thong
Mar 8, 2005·Fertility and Sterility·Daniel B ShapiroZsolt Peter Nagy
Sep 24, 2004·Gynécologie, obstétrique & fertilité·A DevauxJ de Mouzon
Sep 24, 2004·Gynécologie, obstétrique & fertilité·J-L PoulyUNKNOWN FIVNAT
Jun 12, 2003·Fertility and Sterility·Elisabetta RicciarelliEleuterio R Hernandez
Jul 2, 2003·Fertility and Sterility·Daniel B Shapiro
Jul 2, 2003·Fertility and Sterility·Alan B Copperman
Jun 27, 2003·Trends in Endocrinology and Metabolism : TEM·Bart C J M Fauser, Paul Devroey
May 20, 2004·Reproductive Biomedicine Online·Bulent UrmanKayhan Yakin
Sep 20, 2005·Reproductive Biomedicine Online·Roberto MarciMassimo Moscarini
May 22, 2003·Best Practice & Research. Clinical Obstetrics & Gynaecology·Talha Al-Shawaf, J G Grudzinskas
Jan 24, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Jörg B Engel, Andrew V Schally
Jun 17, 2003·Clinical Obstetrics and Gynecology·Nathalie Chabbert-BuffetPhilippe Bouchard
Feb 4, 2006·Clinical Obstetrics and Gynecology·F Olivennes
Mar 19, 2013·Reproductive Biology and Endocrinology : RB&E·Alan B Copperman, Claudio Benadiva
Jan 17, 2009·Reproductive Biology and Endocrinology : RB&E·Fátima PintoAlberto Barros
Feb 18, 2011·Reproductive Biology and Endocrinology : RB&E·Alberto RevelliLuisa Delle Piane
Jul 6, 2014·Reproductive Biology and Endocrinology : RB&E·Kazem NouriJohannes Ott
Oct 14, 2008·European Journal of Endocrinology·Catherine Hayden
May 25, 2005·Lancet·Bart C J M FauserNick S Macklon
Aug 13, 2011·Journal de gynécologie, obstétrique et biologie de la reproduction·F LamazouR Frydman

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