PMID: 18406776Dec 1, 1996Paper

GnRH-induced calcium and current oscillations in gonadotrophs

Trends in Endocrinology and Metabolism : TEM
S S Stojilković, M Tomić

Abstract

The rat pituitary gonadotroph is a well-studied cell model for investigation of the oscillatory nature of calcium signaling in agonist-stimulated excitable cells. Cytosolic calcium levels ([Ca(2+)](i)) in gonadotrophs are controlled by two distinct oscillators, a plasma membrane oscillator that generates extracellular calcium-dependent low-amplitude [Ca(2+)](i) spiking in unstimulated cells and an endoplasmic reticulum oscillator that is activated by calcium-mobilizing receptors for GnRH, endothelin, and pituitary adenylate cyclase-activating polypeptide. In this review, the characteristics of the spontaneous and agonist-induced calcium oscillations in gonadotrophs and the coordinate actions of the two oscillators during GnRH action discussed.

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Citations

Aug 7, 2002·Trends in Endocrinology and Metabolism : TEM·Teddy FauquierPatrice Mollard
Dec 1, 1996·Trends in Endocrinology and Metabolism : TEM·P Mollard, W Schlegel
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·J BilliardB Hille
Sep 28, 2004·Theoretical Biology & Medical Modelling·Talitha M WashingtonP Michael Conn
Jul 1, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B OhlssonG N Fredrikson
Jul 24, 2010·Endocrine Reviews·Stanko S StojilkovicRichard Bertram
Feb 9, 2000·American Journal of Physiology. Endocrinology and Metabolism·J J BlumP M Conn
Jun 10, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·F E RebersR W Schulz
Jul 13, 1999·Journal of Endocrinological Investigation·L PinillaE Aguilar
Jun 24, 2017·Frontiers in Endocrinology·Bodil Ohlsson

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