GnRH-mediated desensitization of the pituitary gonadotrope is not calcium dependent

Endocrinology
W A Smith, P M Conn

Abstract

In the present work we describe homologous desensitization of gonadotropin release from pituitary cells in response to short-term exposure to GnRH. Like the release process itself, desensitization requires receptor occupancy by an agonist. In contrast, however, inhibition of LH release by chelation of extracellular calcium or blockade of the calcium ion channel does not inhibit desensitization. Further, stimulation of gonadotropin release by ionophore A23187 (which mobilizes calcium without GnRH receptor occupancy) does not lead to desensitization. These findings indicate that the decrease in pituitary sensitivity to GnRH due to an initial exposure to the peptide can be uncoupled from LH release. The data provide the first evidence of a calcium-independent biological effect of the releasing hormone in cultured pituitary cells.

Citations

Sep 1, 1987·Molecular and Cellular Endocrinology·W C Gorospe, P M Conn
Sep 1, 1988·Molecular and Cellular Endocrinology·W C Gorospe, P M Conn
Jan 1, 1991·Progress in Growth Factor Research·A QayumJ Waxman
Nov 15, 1984·The New England Journal of Medicine·UNKNOWN Leuprolide Study Group
Nov 1, 1985·Journal of Steroid Biochemistry·P M ConnM Bates
Dec 14, 1984·Biochemical and Biophysical Research Communications·E Hazum, I Schvartz
Apr 14, 1986·Biochemical and Biophysical Research Communications·I Schvartz, E Hazum
Oct 30, 1986·Biochemical and Biophysical Research Communications·I Schvartz, E Hazum
Dec 1, 1985·The American Journal of Physiology·H A Jinnah, P M Conn

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