Goat Milk Consumption Enhances Innate and Adaptive Immunities and Alleviates Allergen-Induced Airway Inflammation in Offspring Mice.

Frontiers in Immunology
Hui-Fang KaoJiu-Yao Wang

Abstract

Goat milk (GM), as compared to cow milk (CM), is easier for humans to digest. It also has antioxidant and anti-inflammatory effects and can improve minor digestive disorders and prevent allergic diseases in infants. It is unclear whether GM consumed in pregnant mothers has any protective effects on allergic diseases in infants. In this experimental study with mice, we found GM feeding enhanced immunoglobulin production, antigen-specific (ovalbumin, OVA) immune responses, and phagocytosis activity. The GM-fed mice had an increasing proportion of CD3+ T lymphocytes in the spleen. Splenocytes isolated from these animals also showed significantly increased production of cytokines IFN-γ and IL-10. More importantly, GM feeding during pregnancy and lactation periods can confer protective activity onto offspring by alleviating the airway inflammation of allergic asthma induced by mite allergens. There was a remarkably different composition of gut microbiota between offspring of pregnant mice fed with water or with milk (GM or CM). There was a greater proportion of beneficial bacterial species, such as Akkermansia muciniphila, Bacteroides eggerthii, and Parabacteroides goldsteinii in the gut microbiota of offspring from GM- or CM-fed pr...Continue Reading

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Citations

Jan 26, 2021·Veterinary World·Abdul JabbarImtiaz Ahmad
Jun 15, 2021·Applied Microbiology and Biotechnology·Tatsuro Hagi, Clara Belzer
Jul 27, 2021·Frontiers in Pharmacology·Ziqi ChenLi Deng
Jul 31, 2021·Journal of the Science of Food and Agriculture·María García-BurgosInmaculada López-Aliaga

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Methods Mentioned

BETA
ELISA
enzyme-linked immunosorbent assay
PCA
chip
flow cytometry

Software Mentioned

MiDAS
R
Axiom Microbial Detection Analysis
flexiVent
GraphPad
GraphPad Prism

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