Gob-5 contributes to goblet cell hyperplasia and modulates pulmonary tissue inflammation

American Journal of Respiratory Cell and Molecular Biology
Andrew J LongSamuel J Goldman

Abstract

Gob-5 is a member of the calcium-activated chloride channel family and has been associated with allergic response in mouse models of pulmonary inflammation. Gene expression of Gob-5 has been shown to be induced in allergic airways and has been strongly associated with mucin gene regulation and goblet cell hyperplasia. We investigated the physiologic role of Gob-5 in murine models of pulmonary inflammation using mice deficient in Gob-5. After sensitization and aerosol challenge with ovalbumin (OVA), Gob-5 knockout mice exhibit significantly increased bronchoalveolar lavage (BAL) inflammation as compared with wild-type controls. The augmented inflammation in BAL consisted predominantly of neutrophils. Examination of perivascular inflammation revealed that tissue inflammation was decreased in OVA-challenged Gob-5-/- mice. OVA-challenged Gob-5 knockout mice also had decreased goblet cell hyperplasia as well as decreased mucus production. These mice also had decreased airway hypersensitivity after cholinergic provocation with methacholine. Gob-5 knockout mice were also challenged via intranasal LPS, a TLR-4 agonist. Gob-5-/- mice responded with increased neutrophilic BAL inflammation and decreased perivascular tissue inflammation as...Continue Reading

References

May 1, 1996·American Journal of Respiratory Cell and Molecular Biology·D I BlythD Fattah
Oct 22, 1998·The New England Journal of Medicine·P LangeG Jensen
Dec 12, 2000·The Journal of Allergy and Clinical Immunology·W W BusseS E Wenzel
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·A NakanishiM Fujino
May 23, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Ina Leverkoehne, Achim D Gruber
Jan 23, 2003·Annals of the New York Academy of Sciences·Massoud DaheshiaAnne Minnich
Mar 11, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Gregory S WhiteheadDavid A Schwartz
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Allison L MillerNicholas W Lukacs
Jan 13, 2004·Nature Medicine·Monique SingerKenneth B Adler
May 8, 2004·American Journal of Respiratory and Critical Care Medicine·Koichi HashimotoR Stokes Peebles
Jan 11, 2005·The European Respiratory Journal·A LindénG P Anderson
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qingsheng ChenJack A Elias
May 28, 2005·The Journal of Biological Chemistry·Adele GibsonNicola Thompson
Jun 11, 2005·American Journal of Respiratory Cell and Molecular Biology·Annette RobichaudSteven Xanthoudakis
Aug 9, 2005·The Journal of Allergy and Clinical Immunology·Douglas A KupermanDavid J Erle

❮ Previous
Next ❯

Citations

Nov 22, 2012·Mucosal Immunology·M B MartinoC M P Ribeiro
Aug 10, 2010·American Journal of Respiratory Cell and Molecular Biology·Nels OlsonAlbert van der Vliet
Mar 1, 2012·American Journal of Respiratory Cell and Molecular Biology·Lars MundhenkAchim D Gruber
Aug 13, 2011·American Journal of Respiratory Cell and Molecular Biology·Lori J FitzCara M M Williams
May 10, 2008·Journal of Leukocyte Biology·Beatriz Hernandez-NovoaJoseph A Kovacs
Aug 24, 2013·Environmental Health Perspectives·Kathryn A RamseyGraeme R Zosky
Dec 19, 2013·PloS One·John C H ChingMatthew E Loewen
Jul 28, 2012·Biomarker Insights·Jennifer LoutenMaribel Beaumont
Jul 19, 2013·Journal of Allergy·Norah G VerboutStephanie A Shore
Sep 9, 2010·Digestive Diseases and Sciences·Sara PadidarJanice E Drew
Jul 1, 2009·The Journal of Cell Biology·Russell E McConnellMatthew J Tyska
May 4, 2013·Experimental Lung Research·Olivier BoucheratChristophe Delacourt
Feb 9, 2016·Journal of Inflammation·Nancy A EricksonAchim D Gruber
Sep 15, 2015·Chemico-biological Interactions·Christina BrandenbergerJack R Harkema
Jul 24, 2015·American Journal of Respiratory Cell and Molecular Biology·Chee Bing OngJack R Harkema
Dec 13, 2007·The Journal of Allergy and Clinical Immunology·Stephen T Holgate
May 24, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Stephen T Holgate
Mar 2, 2012·Allergology International : Official Journal of the Japanese Society of Allergology·Mitsuko KondoAtsushi Nagai
Jan 23, 2008·Allergology International : Official Journal of the Japanese Society of Allergology·Stephen T Holgate
Jun 7, 2014·Neuroscience Letters·Matthias EbbinghausHans-Georg Schaible
Sep 13, 2014·Histochemistry and Cell Biology·Kristina DietertAchim D Gruber
Nov 28, 2015·Mediators of Inflammation·Monica Sala-RabanalTom J Brett
Jul 11, 2007·Journal of Endotoxin Research·Hans-Peter HauberPeter Zabel
Jan 19, 2019·The European Respiratory Journal·Donna M SmallClifford C Taggart
Jul 9, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Roy H E ClootsS Eleonore Köhler
Nov 9, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ning ShiShi-You Chen
Aug 4, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xue ZhangYuehai Ke
Feb 15, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dina SchneiderMarc B Hershenson
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karina CklessYvonne M W Janssen-Heininger
Nov 7, 2019·Bioscience, Biotechnology, and Biochemistry·Junfeng LiYongde Jin
Jan 6, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michelle L ManniJohn F Alcorn
Apr 12, 2019·American Journal of Respiratory and Critical Care Medicine·Gang ChenRichard C Boucher
Jul 3, 2021·Biomedicines·Jeng-Chang ChenMing-Ling Kuo
Dec 7, 2007·Gastroenterology·Fiona D YoungRichard F Rozmahel

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