Goblet cell carcinoid of the appendix - diagnostic challenges and treatment updates: a case report and review of the literature

Journal of Medical Case Reports
Gregory GilmoreSubramanyeswara R Arekapudi

Abstract

Goblet cell carcinoid is a rare but distinct entity of appendiceal tumors which is a hybrid or mixed tumor consisting of both epithelial (glandular) and neuroendocrine elements containing goblet cells. This entity is important to recognize and appropriately grade as it tends to be more aggressive than typical carcinoid tumors, often presenting with metastatic disease. As a result, the 5-year overall survival is 14-22% in stage III-IV disease. GCC therefore warrants more aggressive surgical and medical (chemotherapy) interventions than typical carcinoid tumors. Through this case report we give a brief update on GCC pathological features, staging, surgical management, and review the literature as a guide to indications for chemotherapy and choice of agents. We present the case of a 77-year-old Caucasian man with a history of stage I adenocarcinoma of transverse colon status post transverse colectomy who was incidentally found on surveillance colonoscopy to have an abnormal appendiceal orifice lesion. A biopsy revealed an appendiceal goblet cell carcinoid and he underwent a right hemicolectomy which revealed a pathologic stage III GCC for which he received eight cycles of adjuvant chemotherapy with capecitabine. It is essential th...Continue Reading

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Citations

Oct 18, 2019·Molecular and Clinical Oncology·Alejandro LivoffMoshe Schaffer
Sep 30, 2020·Clinical Journal of Gastroenterology·Junichi KatoMasahito Shimizu
Jul 20, 2020·Surgical Case Reports·Yoshiyuki InoueNaohiro Sata
Mar 27, 2021·American Society of Clinical Oncology Educational Book·Richard S HoehnNathan Bahary
Dec 7, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Amit SarkarDavid L Morris

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Methods Mentioned

BETA
biopsies
surgical resection

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